ARG66771
anti-Calcitonin antibody [SQab20204]
anti-Calcitonin antibody [SQab20204] for IHC-Formalin-fixed paraffin-embedded sections and Human
Overview
| Product Description | Recombinant Rabbit Monoclonal antibody [SQab20204] recognizes Calcitonin |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IHC-P |
| Host | Rabbit |
| Clonality | Monoclonal |
| Clone | SQab20204 |
| Isotype | IgG |
| Target Name | Calcitonin |
| Antigen Species | Human |
| Immunogen | Synthetic peptide corresponding to residues in Human Calcitonin. |
| Conjugation | Un-conjugated |
| Alternate Names | CALC1; Calcitonin carboxyl-terminal peptide; CCP; PDN-21; CT |
Application Instructions
| Application Suggestion |
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| Application Note | IHC-P: Antigen Retrieval: Heat mediation was performed in Tris/EDTA buffer (pH 9.0). * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
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| Positive Control | Medullary thyroid carcinoma. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein A. |
| Buffer | PBS, 0.01% Sodium azide, 40% Glycerol and 0.05% BSA. |
| Preservative | 0.01% Sodium azide |
| Stabilizer | 40% Glycerol and 0.05% BSA |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | CALCA |
| Gene Full Name | Calcitonin |
| Background | This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator and as an antimicrobial peptide while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2014] |
| Function | Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones. Katacalcin is a potent plasma calcium-lowering peptide. [UniProt] |
| Cellular Localization | Secreted. [UniProt] |
| Calculated MW | 14 kDa |
Images (1) Click the Picture to Zoom In
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ARG66771 anti-Calcitonin antibody [SQab20204] IHC-P image
Immunohistochemistry: Formalin/PFA-fixed and paraffin-embedded Human medullary thyroid carcinoma tissue. Antigen Retrieval: Heat mediation was performed in Tris/EDTA buffer (pH 9.0). The tissue section was stained with ARG66771 anti-Calcitonin antibody [SQab20204] at 18°C - 25°C for 30 minutes.
