ARG44590
anti-CYP3A4 antibody
anti-CYP3A4 antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes CYP3A4 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | ICC/IF, IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | CYP3A4 |
| Antigen Species | Human |
| Immunogen | Recombinant protein of human CYP3A4 (a.a. 244-503). |
| Conjugation | Un-conjugated |
| Alternate Names | CYP3A4; Cytochrome P450 Family 3 Subfamily A Member 4; CYP3A3; Cytochrome P450, Subfamily IIIA (Niphedipine Oxidase), Polypeptide 4; Cytochrome P450, Family 3, Subfamily A, Polypeptide 4; Albendazole Monooxygenase (Sulfoxide-Forming); 1,4-Cineole 2-Exo-Monooxygenase; 1,8-Cineole 2-Exo-Monooxygenase; Cholesterol 25-Hydroxylase; Albendazole Sulfoxidase; Quinine 3-Monooxygenase; Cytochrome P450 NF-25; Cytochrome P450-PCN1; Cytochrome P450 3A4; Cytochrome P450 3A3; Cytochrome P450 HLp; Nifedipine Oxidase; EC 1.14.14.1; CYPIIIA3; CYPIIIA4; Cytochrome P450, Subfamily IIIA (Niphedipine Oxidase), Polypeptide 3; Taurochenodeoxycholate 6-Alpha-Hydroxylase; Glucocorticoid-Inducible P450; P450-III, Steroid Inducible; EC 1.14.14.56; EC 1.14.14.73; EC 1.14.14.55; P450PCN1; P450C3; CYP3A; NF-25; VDDR3; CP33; CP34; HLP |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | CYP3A4 |
| Gene Full Name | Cytochrome P450 Family 3 Subfamily A Member 4 |
| Background | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam, erythromycin, and chloroquine. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2020] |
| Function | Also involved in vitamin D catabolism and calcium homeostasis. Catalyzes the inactivation of the active hormone calcitriol (1-alpha,25-dihydroxyvitamin D3).[UniProt] |
| Cellular Localization | Endoplasmic reticulum, Membrane, Microsome.[UniProt] |
| Calculated MW | 57 kDa |
| PTM | Ubl conjugation |
Images (4) Click the Picture to Zoom In
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ARG44590 anti-CYP3A4 antibody ICC/IF image
Immunofluorescence: HeLa stained with ARG44590 anti-CYP3A4 antibody at 1:100 dilution.
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ARG44590 anti-CYP3A4 antibody WB image
Western blot: 293F cells transfected with CYP3A4 stained with ARG44590 anti-CYP3A4 antibody at 1:1000 dilution.
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ARG44590 anti-CYP3A4 antibody IHC-P image
Immunohistochemistry: Rat ovary stained with ARG44590 anti-CYP3A4 antibody at 1:100 dilution.
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ARG44590 anti-CYP3A4 antibody IHC-P image
Immunohistochemistry: Mouse liver stained with ARG44590 anti-CYP3A4 antibody at 1:100 dilution.
