ARG54407
anti-CXCR6 / Bonzo antibody
anti-CXCR6 / Bonzo antibody for Western blot and Human
Immune System antibody; Microbiology and Infectious Disease antibody
Overview
| Product Description | Rabbit Polyclonal antibody recognizes CXCR6 / Bonzo |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | WB |
| Specificity | This antibody recognizes full-length Bonzo (40 kD). |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | CXCR6 / Bonzo |
| Antigen Species | Human |
| Immunogen | Peptide corresponding to aa 319-338 at the C-terminus of human Bonzo. The sequence of this peptide is identical to those of macaque and African green monkey. |
| Conjugation | Un-conjugated |
| Alternate Names | CDw186; BONZO; STRL33; CXCR-6; TYMSTR; C-X-C chemokine receptor type 6; G-protein coupled receptor STRL33; CD antigen CD186; G-protein coupled receptor bonzo; CD186; CXC-R6 |
Application Instructions
| Application Note | Western blot: use at 1:1,000 dilution. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
|---|---|
| Positive Control | SW1353 |
Properties
| Form | Liquid |
|---|---|
| Purification | Immunoaffinity chroma-tography |
| Buffer | PBS (pH 7.4) and 0.02% Sodium azide |
| Preservative | 0.02% Sodium azide |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | CXCR6 |
| Gene Full Name | chemokine (C-X-C motif) receptor 6 |
| Background | Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) require coreceptors in addition to CD4 to infect target cells. Some G protein-coupled receptors in the chemokine receptor family, including CCR5, CXCR4, CCR3, and CCR2b, have previously been identified as HIV coreceptors. An orphan G protein-coupled receptor designated Bonzo was recently cloned and identified as a HIV-1 and -2 and SIV coreceptor (also called STRL33 and TYMSTR). The messenger RNA for Bonzo is expressed in lymphoid tissues and activated peripheral blood lymphocytes. |
| Function | Receptor for the C-X-C chemokine CXCL16. Used as a coreceptor by SIVs and by strains of HIV-2 and m-tropic HIV-1. [UniProt] |
| Research Area | Immune System antibody; Microbiology and Infectious Disease antibody |
| Calculated MW | 39 kDa |
