ARG67142
anti-CXCR4 antibody
anti-CXCR4 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes CXCR4 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | CXCR4 |
| Antigen Species | Human |
| Immunogen | Synthetic peptide corresponding to Human CXCR4. |
| Conjugation | Un-conjugated |
| Alternate Names | CXCR4; C-X-C Motif Chemokine Receptor 4; LESTR; Fusin; HM89; D2S201E; NPYY3R; HSY3RR; NPY3R; CD184; NPYR; Leukocyte-Derived Seven Transmembrane Domain Receptor; Lipopolysaccharide-Associated Protein 3; Stromal Cell-Derived Factor 1 Receptor; Chemokine (C-X-C Motif) Receptor 4; C-X-C Chemokine Receptor Type 4; LPS-Associated Protein 3; SDF-1 Receptor; CD184 Antigen; LAP-3; NPYRL; FB22; LCR1 ; Seven-Transmembrane-Segment Receptor, Spleen; Chemokine (C-X-C Motif), Receptor 4 (Fusin); Seven Transmembrane Helix Receptor; Neuropeptide Y Receptor Y3; Neuropeptide Y3 Receptor; WHIMS1; CXC-R4; CXCR-4; WHIMS; LAP3; WHIM |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Observed Size | 47-64 kda |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity chromatography purified |
| Buffer | PBS, 0.02% Sodium azide, 0.5% BSA and 50% Glycerol |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 0.5% BSA, 50% Glycerol |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | CXCR4 |
| Gene Full Name | C-X-C Motif Chemokine Receptor 4 |
| Background | This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] |
| Function | Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. [UniProt] |
| Cellular Localization | Cell junction, Cell membrane, Endosome, Lysosome, Membrane. [UniProt] |
| Calculated MW | 40 kDa |
| PTM | Disulfide bond, Glycoprotein, Isopeptide bond, Phosphoprotein, Proteoglycan, Sulfation, Ubl conjugation. [UniProt] |
Images (3) Click the Picture to Zoom In
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ARG67142 anti-CXCR4 antibody IHC-P image
Immunohistochemistry: Human Breast Carcinoma stained with ARG67142 anti-CXCR4 antibody at 1:200 dilution.
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ARG67142 anti-CXCR4 antibody WB image
Western blot: Rat Brai, HeLa and HEK293 stained with ARG67142 anti-CXCR4 antibody at 1:1000 dilution.
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ARG67142 anti-CXCR4 antibody IHC-P image
Immunohistochemistry: Human Tonsil Tissue stained with ARG67142 anti-CXCR4 antibody at 1:200 dilution.
