ARG56413
anti-CX3CR1 antibody
anti-CX3CR1 antibody for Flow cytometry,ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes CX3CR1 |
|---|---|
| Tested Reactivity | Hu, Rat |
| Tested Application | FACS, ICC/IF, IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | CX3CR1 |
| Antigen Species | Human |
| Immunogen | Synthetic peptide (20 aa) within the first 50 aa of Human CX3CR1. |
| Conjugation | Un-conjugated |
| Alternate Names | CMK-BRL1; GPR13; CX3CR1; CMK-BRL-1; C-X3-C CKR-1; CX3C chemokine receptor 1; V28; CCRL1; GPRV28; CMKBRL1; G-protein coupled receptor 13; CMKDR1; Beta chemokine receptor-like 1; Fractalkine receptor |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||||
| Positive Control | Human Spleen Tissue Lysate |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | PBS and 0.02% Sodium azide |
| Preservative | 0.02% Sodium azide |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | CX3CR1 |
| Gene Full Name | chemokine (C-X3-C motif) receptor 1 |
| Background | Fractalkine is a transmembrane protein and chemokine involved in the adhesion and migration of leukocytes. The protein encoded by this gene is a receptor for fractalkine. The encoded protein also is a coreceptor for HIV-1, and some variations in this gene lead to increased susceptibility to HIV-1 infection and rapid progression to AIDS. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2010] |
| Function | Receptor for the CX3C chemokine fractalkine and mediates both its adhesive and migratory functions. Acts as coreceptor with CD4 for HIV-1 virus envelope protein (in vitro). Isoform 2 and isoform 3 seem to be more potent HIV-1 coreceptors than isoform 1. [UniProt] |
| Calculated MW | 40 kDa |
| PTM | This protein is not N-glycosylated which is unusual for G-protein-coupled receptors. |
Images (4) Click the Picture to Zoom In
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ARG56413 anti-CX3CR1 antibody ICC/IF image
Immunofluorescence: Human Heart cells stained with ARG56413 anti-CX3CR1 antibody at 10 ug/ml dilution.
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ARG56413 anti-CX3CR1 antibody FACS image
Flow Cytometry: THP-1 cells stained with ARG56413 anti-CX3CR1 antibody at 0.1 µg/ml dilution. Green: Isotype control. Red: primary antibody.
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ARG56413 anti-CX3CR1 antibody IHC-P image
Immunohistochemistry: Human heart tissue stained with ARG56413 anti-CX3CR1 antibody at 2 ug/ml dilution.
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ARG56413 anti-CX3CR1 antibody WB image
Western blot: Human spleen lysate stained with ARG56413 anti-CX3CR1 antibody at 1 µg/ml dilution in the absence (lane 1) or presence of blocking peptide (lane 2).
