ARG59428
anti-CRLF2 antibody
anti-CRLF2 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes CRLF2 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IHC-P, WB |
| Specificity | At least two isoforms of CRLF2 are known to exist; this antibody will recognize both isoforms. |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | CRLF2 |
| Antigen Species | Human |
| Immunogen | A 19 amino acid synthetic peptide within aa. 140-190 of Human CRLF2. |
| Conjugation | Un-conjugated |
| Alternate Names | CRL2; Cytokine receptor-like 2; Cytokine receptor-like factor 2; Thymic stromal lymphopoietin protein receptor; TSLP receptor; TSLPR; IL-XR; CRLF2Y |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Positive Control | Human liver | ||||||
| Observed Size | 53 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | PBS and 0.02% Sodium azide |
| Preservative | 0.02% Sodium azide |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | CRLF2 |
| Gene Full Name | cytokine receptor-like factor 2 |
| Background | This gene encodes a member of the type I cytokine receptor family. The encoded protein is a receptor for thymic stromal lymphopoietin (TSLP). Together with the interleukin 7 receptor (IL7R), the encoded protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Rearrangement of this gene with immunoglobulin heavy chain gene (IGH) on chromosome 14, or with P2Y purinoceptor 8 gene (P2RY8) on the same X or Y chromosomes is associated with B-progenitor acute lymphoblastic leukemia (ALL) and Down syndrome ALL. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014] |
| Function | Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2 (By similarity). Implicated in the development of the hematopoietic system. [UniProt] |
| Cellular Localization | Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted. [UniProt] |
| Calculated MW | 42 kDa |
Images (3) Click the Picture to Zoom In
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ARG59428 anti-CRLF2 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human liver stained with ARG59428 anti-CRLF2 antibody at 20 µg/ml dilution.
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ARG59428 anti-CRLF2 antibody WB image
Western blot: Human liver lysate stained with ARG59428 anti-CRLF2 antibody at 0.5, 1 and 2 µg/ml dilution.
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ARG59428 anti-CRLF2 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human liver stained with ARG59428 anti-CRLF2 antibody at 5 µg/ml dilution.
