ARG59582
anti-CRHBP antibody
anti-CRHBP antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes CRHBP |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | ICC/IF, IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | CRHBP |
| Antigen Species | Human |
| Immunogen | Recombinant fusion protein corresponding to aa. 25-322 of Human CRHBP (NP_001873.2). |
| Conjugation | Un-conjugated |
| Alternate Names | CRFBP; CRH-BP; CRF-binding protein; Corticotropin-releasing hormone-binding protein; Corticotropin-releasing factor-binding protein; CRF-BP |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| Positive Control | Rat brain | ||||||||
| Observed Size | 37 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # P24387 Human Corticotropin-releasing factor-binding protein Swiss-port # Q60571 Mouse Corticotropin-releasing factor-binding protein |
|---|---|
| Gene Symbol | CRHBP |
| Gene Full Name | corticotropin releasing hormone binding protein |
| Background | Corticotropin-releasing hormone is a potent stimulator of synthesis and secretion of preopiomelanocortin-derived peptides. Although CRH concentrations in the human peripheral circulation are normally low, they increase throughout pregnancy and fall rapidly after parturition. Maternal plasma CRH probably originates from the placenta. Human plasma contains a CRH-binding protein which inactivates CRH and which may prevent inappropriate pituitary-adrenal stimulation in pregnancy. [provided by RefSeq, Jul 2008] |
| Function | Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. [UniProt] |
| Cellular Localization | Secreted. [UniProt] |
| Calculated MW | 36 kDa |
Images (2) Click the Picture to Zoom In
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ARG59582 anti-CRHBP antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Rat heart stained with ARG59582 anti-CRHBP antibody at 1:100 dilution.
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ARG59582 anti-CRHBP antibody WB image
Western blot: 25 µg of Rat brain lysate stained with ARG59582 anti-CRHBP antibody at 1:1000 dilution.
