ARG63318
anti-COPS2 / TRIP15 antibody
anti-COPS2 / TRIP15 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse
Gene Regulation antibody; Signaling Transduction antibody
Overview
| Product Description | Goat Polyclonal antibody recognizes COPS2 / TRIP15 |
|---|---|
| Tested Reactivity | Hu, Ms |
| Predict Reactivity | Cow, Rat, Dog |
| Tested Application | IHC-P, WB |
| Host | Goat |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | COPS2 / TRIP15 |
| Antigen Species | Human |
| Immunogen | C-LNSLNQAVVSKLA |
| Conjugation | Un-conjugated |
| Alternate Names | Alien homolog; Thyroid receptor-interacting protein 15; COP9 signalosome complex subunit 2; TR-interacting protein 15; SGN2; Signalosome subunit 2; JAB1-containing signalosome subunit 2; ALIEN; CSN2; TRIP-15; TRIP15 |
Application Instructions
| Application Suggestion |
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|---|---|---|---|---|---|---|---|
| Application Note | WB: Recommend incubate at RT for 1h. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Buffer | Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 0.5% BSA |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # P61201 Human COP9 signalosome complex subunit 2 Swiss-port # P61202 Mouse COP9 signalosome complex subunit 2 |
|---|---|
| Gene Symbol | COPS2 |
| Gene Full Name | COP9 signalosome subunit 2 |
| Function | Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1. [UniProt] |
| Research Area | Gene Regulation antibody; Signaling Transduction antibody |
| Calculated MW | 52 kDa |
| PTM | Phosphorylated by CK2 and PKD kinases. |
Images (2) Click the Picture to Zoom In
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ARG63318 anti-COPS2 / TRIP15 antibody WB image
Western Blot: NIH-3T3 lysates (RIPA buffer, 30µg total protein per lane) stained with ARG63318 anti-COPS2 / TRIP15 antibody at 0.03 µg/ml dilution.
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ARG63318 anti-COPS2 / TRIP15 antibody IHC-P image
Immunohistochemistry: In paraffin embedded Human Thyroid Gland stained with ARG63318 anti-COPS2 / TRIP15 antibody shows nclear and cytoplasm staining in activated epithelial cells. Recommended concentration, 3-5µg/ml.
