ARG44317

anti-COL25A1 antibody

anti-COL25A1 antibody for Western blot and Human,Mouse

Overview

Product Description Rabbit Polyclonal antibody recognizes COL25A1
Tested Reactivity Hu, Ms
Tested Application WB
Specificity This antibody is design for isoform 3
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name COL25A1
Antigen Species Human
Immunogen Synthetic peptide
Conjugation Un-conjugated
Alternate Names COL25A1; Collagen Type XXV Alpha 1 Chain; Alzheimer Disease Amyloid-Associated Protein; Collagen Alpha-1(XXV) Chain; CLAC-P; AMY; Collagen-Like Alzheimer Amyloid Plaque Component; Collagenous Alzheimer Amyloid Plaque Component; Collagen, Type XXV, Alpha 1; CFEOM5; CLACP; CLAC

Application Instructions

Application Suggestion
Tested Application Dilution
WB1:500-1:1000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Antigen Affinity Purified
Buffer PBS with 0.02% Sodium azide
Preservative 0.02% Sodium azide
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.

Bioinformation

Database Links

GeneID: 77018 Mouse COL25A1

GeneID: 84570 Human COL25A1

Swiss-port # Q99MQ5 Mouse Collagen alpha-1(XXV) chain

Swiss-port # Q9BXS0 Human Collagen alpha-1(XXV) chain

Gene Symbol COL25A1
Gene Full Name Collagen Type XXV Alpha 1 Chain
Background This gene encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013). Multiple transcript variants encoding different isoforms have been found for this gene.
Function Inhibits fibrillization of amyloid-beta peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin.
Cellular Localization Amyloid, Membrane
Calculated MW 58 kDa
PTM Glycoprotein, Hydroxylation, Pyrrolidone carboxylic acid