ARG44317
anti-COL25A1 antibody
anti-COL25A1 antibody for Western blot and Human,Mouse
Overview
Product Description | Rabbit Polyclonal antibody recognizes COL25A1 |
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Tested Reactivity | Hu, Ms |
Tested Application | WB |
Specificity | This antibody is design for isoform 3 |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | IgG |
Target Name | COL25A1 |
Antigen Species | Human |
Immunogen | Synthetic peptide |
Conjugation | Un-conjugated |
Alternate Names | COL25A1; Collagen Type XXV Alpha 1 Chain; Alzheimer Disease Amyloid-Associated Protein; Collagen Alpha-1(XXV) Chain; CLAC-P; AMY; Collagen-Like Alzheimer Amyloid Plaque Component; Collagenous Alzheimer Amyloid Plaque Component; Collagen, Type XXV, Alpha 1; CFEOM5; CLACP; CLAC |
Application Instructions
Application Suggestion |
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Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
Form | Liquid |
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Purification | Antigen Affinity Purified |
Buffer | PBS with 0.02% Sodium azide |
Preservative | 0.02% Sodium azide |
Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
Bioinformation
Database Links | |
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Gene Symbol | COL25A1 |
Gene Full Name | Collagen Type XXV Alpha 1 Chain |
Background | This gene encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013). Multiple transcript variants encoding different isoforms have been found for this gene. |
Function | Inhibits fibrillization of amyloid-beta peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin. |
Cellular Localization | Amyloid, Membrane |
Calculated MW | 58 kDa |
PTM | Glycoprotein, Hydroxylation, Pyrrolidone carboxylic acid |