ARG44316
anti-COL25A1 antibody
anti-COL25A1 antibody for Western blot and Human,Mouse
Overview
| Product Description | Rabbit Polyclonal antibody recognizes COL25A1 |
|---|---|
| Tested Reactivity | Hu, Ms |
| Tested Application | WB |
| Specificity | This antibody is design for isoform 2 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | COL25A1 |
| Antigen Species | Human |
| Immunogen | Synthetic peptide |
| Conjugation | Un-conjugated |
| Alternate Names | COL25A1; Collagen Type XXV Alpha 1 Chain; Alzheimer Disease Amyloid-Associated Protein; Collagen Alpha-1(XXV) Chain; CLAC-P; AMY; Collagen-Like Alzheimer Amyloid Plaque Component; Collagenous Alzheimer Amyloid Plaque Component; Collagen, Type XXV, Alpha 1; CFEOM5; CLACP; CLAC |
Application Instructions
| Application Suggestion |
|
||||
|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Antigen Affinity Purified |
| Buffer | PBS with 0.02% Sodium azide |
| Preservative | 0.02% Sodium azide |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | COL25A1 |
| Gene Full Name | Collagen Type XXV Alpha 1 Chain |
| Background | This gene encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013). Multiple transcript variants encoding different isoforms have been found for this gene. |
| Function | Inhibits fibrillization of amyloid-beta peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin. |
| Cellular Localization | Amyloid, Membrane |
| Calculated MW | 64 kDa |
| PTM | Glycoprotein, Hydroxylation, Pyrrolidone carboxylic acid |
