ARG41131
anti-CNOT9 / RQCD1 antibody
anti-CNOT9 / RQCD1 antibody for Western blot and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes CNOT9 / RQCD1 |
|---|---|
| Tested Reactivity | Hu |
| Predict Reactivity | Ms |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | CNOT9 / RQCD1 |
| Antigen Species | Human |
| Immunogen | KLH-conjugated synthetic peptide between aa. 106-134 of Human CNOT9 / RQCD1. |
| Conjugation | Un-conjugated |
| Alternate Names | RCD-1; Rcd-1; RCD1; Cell differentiation protein RCD1 homolog; CNOT9; CT129; CCR4-NOT transcription complex subunit 9; CAF40 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein A and immunogen peptide |
| Buffer | PBS and 0.09% (W/V) Sodium azide. |
| Preservative | 0.09% (W/V) Sodium azide |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q92600 Human Cell differentiation protein RCD1 homolog |
|---|---|
| Gene Symbol | RQCD1 |
| Gene Full Name | RCD1 required for cell differentiation1 homolog (S. pombe) |
| Background | This gene encodes a member of the highly conserved RCD1 protein family. The encoded protein is a transcriptional cofactor and a core protein of the CCR4-NOT complex. It may be involved in signal transduction as well as retinoic acid-regulated cell differentiation and development. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2012] |
| Function | Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in down-regulation of MYB- and JUN-dependent transcription. May play a role in cell differentiation (By similarity). Can bind oligonucleotides, such as poly-G, poly-C or poly-T (in vitro), but the physiological relevance of this is not certain. Does not bind poly-A. Enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA, expect ESR1-mediated transcription that is not only slightly increased, if at all. [UniProt] |
| Cellular Localization | Nucleus. Cytoplasm, P-body. Note=NANOS2 promotes its localization to P-body. [UniProt] |
| Calculated MW | 34 kDa |
Images (1) Click the Picture to Zoom In
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ARG41131 anti-CNOT9 / RQCD1 antibody WB image
Western blot: 20 µg of HL-60 whole cell lysate stained with ARG41131 anti-CNOT9 / RQCD1 antibody at 1:500 dilution.
