ARG45681
anti-CES2 antibody
anti-CES2 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse
Overview
| Product Description | Rabbit Polyclonal antibody recognizes CES2 |
|---|---|
| Tested Reactivity | Hu, Ms |
| Tested Application | IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | CES2 |
| Antigen Species | Human |
| Immunogen | Recombinant protein containing to human CES2. |
| Conjugation | Un-conjugated |
| Alternate Names | hCE-2; Methylumbelliferyl-acetate deacetylase 2; EC 3.1.1.84; Carboxylesterase 2; Cocaine esterase; CE-2; iCE; EC 3.1.1.56; CES2A1; PCE-2; EC 3.1.1.1 |
Application Instructions
| Application Suggestion |
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|---|---|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Observed Size | 62 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified |
| Buffer | 0.2% Na2HPO4, 0.9% NaCl and 4% Trehalose. |
| Stabilizer | 4% Trehalose |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | CES2 |
| Gene Full Name | carboxylesterase 2 |
| Background | This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. The protein encoded by this gene is the major intestinal enzyme and functions in intestine drug clearance. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2010] |
| Function | Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine. [UniProt] |
| Cellular Localization | Endoplasmic reticulum lumen. [UniProt] |
| PTM | Glycosylated. [UniProt] |
Images (3) Click the Picture to Zoom In
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ARG45681 anti-CES2 antibody IHC-P image
Immunohistochemistry: Human liver cancer stained with ARG45681 anti-CES2 antibody at 2 μg/ml dilution.
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ARG45681 anti-CES2 antibody WB image
Western blot: HepG2 stained with ARG45681 anti-CES2 antibody at 0.5 μg/ml dilution.
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ARG45681 anti-CES2 antibody WB image
Western blot: Mouse liver stained with ARG45681 anti-CES2 antibody at 0.5 μg/ml dilution.
