ARG62582
anti-CDKN1C / p57 Kip2 antibody [KP39]
anti-CDKN1C / p57 Kip2 antibody [KP39] for IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation and Human,Mouse,Rat
Cancer antibody; Cell Biology and Cellular Response antibody; Gene Regulation antibody
Overview
| Product Description | Mouse Monoclonal antibody [KP39] recognizes CDKN1C / p57 Kip2 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | IHC-P, IP |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | KP39 |
| Isotype | IgG2b |
| Target Name | CDKN1C / p57 Kip2 |
| Antigen Species | Human |
| Immunogen | Recombinant full length protein (Human). |
| Conjugation | Un-conjugated |
| Alternate Names | Cyclin-dependent kinase inhibitor p57; BWS; WBS; BWCR; KIP2; Cyclin-dependent kinase inhibitor 1C; p57; p57Kip2 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | IgG purified |
| Buffer | 10mM PBS (pH 7.4), 0.2% BSA and 0.09% Sodium azide |
| Preservative | 0.09% Sodium azide |
| Stabilizer | 0.2% BSA |
| Concentration | 0.2 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # P49918 Human Cyclin-dependent kinase inhibitor 1C Swiss-port # P49919 Mouse Cyclin-dependent kinase inhibitor 1C |
|---|---|
| Gene Symbol | CDKN1C |
| Gene Full Name | cyclin-dependent kinase inhibitor 1C (p57, Kip2) |
| Background | This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2010] |
| Function | Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life. [UniProt] |
| Cellular Localization | Nucleus |
| Research Area | Cancer antibody; Cell Biology and Cellular Response antibody; Gene Regulation antibody |
| Calculated MW | 32 kDa |
Clone References
BMP10 is essential for maintaining cardiac growth during murine cardiogenesis.
IHC / Mouse
Expression and activity of the CDK inhibitor p57Kip2 in chondrocytes undergoing hypertrophic differentiation.
WB / Rat
