ARG45747
anti-CDK5RAP2 antibody
anti-CDK5RAP2 antibody for ICC/IF,Western blot and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes CDK5RAP2 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | ICC/IF, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | CDK5RAP2 |
| Antigen Species | Human |
| Immunogen | Recombinant protein containing to human CDK5RAP2. |
| Conjugation | Un-conjugated |
| Alternate Names | CDK5RAP2; CDK5 Regulatory Subunit Associated Protein 2; CEP215; C48; CDK5 Regulatory Subunit-Associated Protein 2; CDK5 Activator-Binding Protein C48; Centrosomin; FLJ10867; MCPH3; Microcephaly, Primary Autosomal Recessive 3; Centrosome-Associated Protein 215; Centrosomal Protein 215 KDa; KIAA1633 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Observed Size | 250 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified |
| Buffer | 0.2% Na2HPO4, 0.9% NaCl and 4% Trehalose. |
| Stabilizer | 4% Trehalose |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q96SN8 Human CDK5 regulatory subunit-associated protein 2 |
|---|---|
| Gene Symbol | CDK5RAP2 |
| Gene Full Name | CDK5 Regulatory Subunit Associated Protein 2 |
| Background | This gene encodes a regulator of CDK5 (cyclin-dependent kinase 5) activity. The protein encoded by this gene is localized to the centrosome and Golgi complex, interacts with CDK5R1 and pericentrin (PCNT), plays a role in centriole engagement and microtubule nucleation, and has been linked to primary microcephaly and Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013] |
| Function | Potential regulator of CDK5 activity via its interaction with CDK5R1. Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation (By similarity). Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter. Together with EB1/MAPRE1, may promote microtubule polymerization, bundle formation, growth and dynamics at the plus ends. Regulates centrosomal maturation by recruitment of the gamma-tubulin ring complex (gamma-TuRC) onto centrosomes. [UniProt] |
| Cellular Localization | Cytoplasm; Cytoskeleton; Golgi apparatus; Microtubule. [UniProt] |
| Calculated MW | 215 kDa |
| PTM | Phosphoprotein. [UniProt] |
