ARG57075
anti-CDC37 antibody [3G7]
anti-CDC37 antibody [3G7] for Western blot and Human
Overview
Product Description | Mouse Monoclonal antibody [3G7] recognizes CDC37 |
---|---|
Tested Reactivity | Hu |
Tested Application | WB |
Host | Mouse |
Clonality | Monoclonal |
Clone | 3G7 |
Isotype | IgG1, kappa |
Target Name | CDC37 |
Antigen Species | Human |
Immunogen | Recombinant fragment around aa. 1-378 of Human Cdc37. |
Conjugation | Un-conjugated |
Alternate Names | p50Cdc37; Hsp90 chaperone protein kinase-targeting subunit; Hsp90 co-chaperone Cdc37; P50CDC37 |
Application Instructions
Application Suggestion |
|
||||
---|---|---|---|---|---|
Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
Form | Liquid |
---|---|
Purification | Purification with Protein A. |
Buffer | PBS (pH 7.4), 0.02% Sodium azide and 10% Glycerol. |
Preservative | 0.02% Sodium azide |
Stabilizer | 10% Glycerol |
Concentration | 1 mg/ml |
Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
Database Links | |
---|---|
Gene Symbol | CDC37 |
Gene Full Name | cell division cycle 37 |
Background | The protein encoded by this gene is highly similar to Cdc 37, a cell division cycle control protein of Sacchromyces cerevisiae. This protein is a molecular chaperone with specific function in cell signal transduction. It has been shown to form complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. It is thought to play a critical role in directing Hsp90 to its target kinases. [provided by RefSeq, Jul 2008] |
Function | Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity. [UniProt] |
Calculated MW | 44 kDa |
PTM | Constitutively sumoylated by UBE2I. |
Images (1) Click the Picture to Zoom In