ARG21401
anti-CD79b antibody [CB3-1] (FITC)
anti-CD79b antibody [CB3-1] (FITC) for Flow cytometry,Western blot and Human
Overview
| Product Description | FITC-conjugated Mouse Monoclonal antibody [CB3-1] recognizes CD79b |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | FACS, WB |
| Specificity | Human CD79b. The clone CB3-1 reacts with the β chain of CD79. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | CB3-1 |
| Isotype | IgG1, kappa |
| Target Name | CD79b |
| Antigen Species | Human |
| Immunogen | Ramos B cells |
| Conjugation | FITC |
| Alternate Names | B29; B-cell-specific glycoprotein B29; Ig-beta; B-cell antigen receptor complex-associated protein beta chain; Immunoglobulin-associated B29 protein; AGM6; IGB; CD antigen CD79b |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Buffer | PBS and 0.1% Sodium azide. |
| Preservative | 0.1% Sodium azide |
| Storage Instruction | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # P40259 Human B-cell antigen receptor complex-associated protein beta chain |
|---|---|
| Gene Symbol | CD79B |
| Gene Full Name | CD79b molecule, immunoglobulin-associated beta |
| Background | The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008] |
| Function | Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation. [UniProt] |
| Calculated MW | 26 kDa |
| PTM | Phosphorylated on tyrosine upon B-cell activation by SRC-type Tyr-kinases such as BLK, LYN and SYK. |
