ARG22042
anti-CD49e / Integrin alpha 5 antibody [5H10.27]
anti-CD49e / Integrin alpha 5 antibody [5H10.27] for Blocking,Flow cytometry,IHC-Frozen sections and Mouse
Overview
| Product Description | Rat Monoclonal antibody [5H10.27] recognizes CD49e / Integrin alpha 5 |
|---|---|
| Tested Reactivity | Ms |
| Tested Application | BL, FACS, IHC-Fr |
| Specificity | Mouse CD49e |
| Host | Rat |
| Clonality | Monoclonal |
| Clone | 5H10.27 |
| Isotype | IgG2a, kappa |
| Target Name | CD49e / Integrin alpha 5 |
| Antigen Species | Mouse |
| Immunogen | C57BL/6 x A/J F1 Mouse mast cell line MC/9 |
| Conjugation | Un-conjugated |
| Alternate Names | CD49e; CD49 antigen-like family member E; Integrin alpha-F; Fibronectin receptor subunit alpha; CD antigen CD49e; VLA-5; FNRA; VLA5A; Integrin alpha-5 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Buffer | BBS (pH 8.2) |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | ITGA5 |
| Gene Full Name | integrin alpha 5 (fibronectin receptor alpha) |
| Background | The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. Integrin alpha 5 and integrin alpha V chains are produced by distinct genes. [provided by RefSeq, Jan 2015] |
| Function | Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. [UniProt] |
| Highlight | Related products: CD49e antibodies; Anti-Rat IgG secondary antibodies; |
| Calculated MW | 115 kDa |
| PTM | Proteolytic cleavage by PCSK5 mediates activation of the precursor. |
