ARG21042
anti-CD49d / LPAM1 / Integrin alpha 4 antibody [DATK32]
anti-CD49d / LPAM1 / Integrin alpha 4 antibody [DATK32] for Blocking,Flow cytometry,IHC-Frozen sections,Immunoprecipitation and Mouse
Overview
| Product Description | Rat Monoclonal antibody [DATK32] recognizes CD49d / LPAM1 / Integrin alpha 4 |
|---|---|
| Tested Reactivity | Ms |
| Tested Application | BL, FACS, IHC-Fr, IP |
| Specificity | Mouse LPAM-1. The clone DATK32 recognizes a conformational epitope on the heterodimer. |
| Host | Rat |
| Clonality | Monoclonal |
| Clone | DATK32 |
| Isotype | IgG2a, kappa |
| Target Name | CD49d / LPAM1 / Integrin alpha 4 |
| Antigen Species | Mouse |
| Immunogen | AKR/Cum mouse T lymphoma cell line TK-1 |
| Conjugation | Un-conjugated |
| Alternate Names | CD49 antigen-like family member D; VLA-4 subunit alpha; CD49D; Integrin alpha-IV; CD antigen CD49d; Integrin alpha-4; IA4 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Buffer | BBS (pH 8.2) |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | ITGA4 |
| Gene Full Name | integrin alpha 4 |
| Background | The product of this gene belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an alpha 4 chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Alpha 4 chain associates with either beta 1 chain or beta 7 chain. [provided by RefSeq, Jul 2008] |
| Function | Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells. [UniProt] |
| Calculated MW | 115 kDa |
| PTM | Phosphorylation on Ser-1027 inhibits PXN binding. |
Images (1) Click the Picture to Zoom In
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ARG21042 anti-CD49d / LPAM1 / Integrin alpha 4 antibody [DATK32] FACS image
Flow Cytometry: BALB/c Mouse splenocytes stained with ARG21042 anti-CD49d / LPAM1 / Integrin alpha 4 antibody [DATK32] followed by ARG23825 Mouse anti-Rat IgG2a antibody [2A8F4] (Cy5).
