ARG22420
anti-CD49a / Integrin alpha 1 antibody [TS2/7]
anti-CD49a / Integrin alpha 1 antibody [TS2/7] for CyTOF®-candidate,Flow cytometry,IHC-Frozen sections,Immunoprecipitation and Human
Overview
Product Description | Mouse Monoclonal antibody [TS2/7] recognizes CD49a / Integrin alpha 1 This antibody recognizes the human alpha 1 integrin sub-unit, which forms the VLA-1 heterodimer in association with the beta 1 integrin. VLA-1 is a receptor for collagen and laminin, and is expressed by chronically activated T cells, melanoma cells and smooth muscle cells. |
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Tested Reactivity | Hu |
Tested Application | CyTOF®-candidate, FACS, IHC-Fr, IP |
Host | Mouse |
Clonality | Monoclonal |
Clone | TS2/7 |
Isotype | IgG1 |
Target Name | CD49a / Integrin alpha 1 |
Antigen Species | Human |
Immunogen | Human CTL line directed against HLA-DR. |
Conjugation | Un-conjugated |
Alternate Names | VLA-1; CD49a; Integrin alpha-1; Laminin and collagen receptor; VLA1; CD antigen CD49a; CD49 antigen-like family member A |
Application Instructions
Application Suggestion |
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Application Note | FACS: Use 10ul of the suggested working dilution to label 10^6 cells in 100ul. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
Form | Liquid |
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Purification | Purification with Protein G. |
Buffer | PBS and 0.09% Sodium azide |
Preservative | 0.09% Sodium azide |
Concentration | 1 mg/ml |
Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
Database Links | |
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Gene Symbol | ITGA1 |
Gene Full Name | integrin, alpha 1 |
Background | This gene encodes the alpha 1 subunit of integrin receptors. This protein heterodimerizes with the beta 1 subunit to form a cell-surface receptor for collagen and laminin. The heterodimeric receptor is involved in cell-cell adhesion and may play a role in inflammation and fibrosis. The alpha 1 subunit contains an inserted (I) von Willebrand factor type I domain which is thought to be involved in collagen binding. [provided by RefSeq, Jul 2008] |
Function | Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth. [UniProt] |
Highlight | Related products: CD49a antibodies; Anti-Mouse IgG secondary antibodies; Related news: CyTOF-candidate Antibodies |
Calculated MW | 131 kDa |
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