ARG66145
anti-CD262 / TRAIL R2 antibody (Biotin)
anti-CD262 / TRAIL R2 antibody (Biotin) for ELISA,Western blot and Human
Overview
| Product Description | Biotin-conjugated Rabbit Polyclonal antibody recognizes CD262 / TRAIL R2 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | ELISA, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | CD262 / TRAIL R2 |
| Antigen Species | Human |
| Immunogen | E. coli derived recombinant Human DR5. (MESALITQQD LAPQQRVAPQ QKRSSPSEGL CPPGHHISED GRDCISCKYG QDYSTHWNDL LFCLRCTRCD SGEVELSPCT TTRNTVCQCE EGTFREEDSP EMCRKCRTGC PRGMVKVGDC TPWSDIECVH KES) |
| Conjugation | Biotin |
| Alternate Names | TRICK2A; TRICK2B; KILLER; TRAILR2; TNF-related apoptosis-inducing ligand receptor 2; DR5; CD antigen CD262; TRICK2; CD262; KILLER/DR5; Tumor necrosis factor receptor superfamily member 10B; Death receptor 5; TRAIL-R2; TRAIL receptor 2; TRICKB; ZTNFR9 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purified by affinity chromatography. |
| Buffer | PBS (pH 7.2) |
| Concentration | 1 mg/ml |
| Storage Instruction | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # O14763 Human Tumor necrosis factor receptor superfamily member 10B |
|---|---|
| Gene Symbol | TNFRSF10B |
| Gene Full Name | tumor necrosis factor receptor superfamily, member 10b |
| Background | The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq, Mar 2009] |
| Function | Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis. [UniProt] |
| Calculated MW | 48 kDa |
Images (4) Click the Picture to Zoom In
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ARG66145 anti-CD262 / TRAIL R2 antibody (Biotin) WB image
Western blot: 250 - 0.24 ng of Human sTRAIL Receptor-2 stained with ARG66145 anti-CD262 / TRAIL R2 antibody (Biotin), under non-reducing conditions.
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ARG66145 anti-CD262 / TRAIL R2 antibody (Biotin) standard curve image
Direct ELISA: ARG66145 anti-CD262 / TRAIL R2 antibody (Biotin) at 0.25 - 1.0 µg/ml results of a typical standard run with optical density reading at 405 - 650 nm.
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ARG66145 anti-CD262 / TRAIL R2 antibody (Biotin) WB image
Western blot: 250 - 0.24 ng of Human sTRAIL Receptor-2 stained with ARG66145 anti-CD262 / TRAIL R2 antibody (Biotin), under reducing conditions.
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ARG66145 anti-CD262 / TRAIL R2 antibody (Biotin) standard curve image
Sandwich ELISA: ARG66145 anti-CD262 / TRAIL R2 antibody (Biotin) as a detection antibody at 0.25 - 1.0 µg/ml combined with ARG66144 anti-DR5 antibody as a capture antibody. Results of a typical standard run with optical density reading at 405 - 650 nm.
