ARG22343
anti-CD262 / TRAIL R2 antibody
anti-CD262 / TRAIL R2 antibody for Flow cytometry,ICC/IF,Western blot and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes CD262 / TRAIL R2 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | FACS, ICC/IF, WB |
| Specificity | Human DR5 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | CD262 / TRAIL R2 |
| Antigen Species | Human |
| Immunogen | Recombinant Human DR5 protein. |
| Conjugation | Un-conjugated |
| Alternate Names | TRICK2A; TRICK2B; KILLER; TRAILR2; TNF-related apoptosis-inducing ligand receptor 2; DR5; CD antigen CD262; TRICK2; CD262; KILLER/DR5; Tumor necrosis factor receptor superfamily member 10B; Death receptor 5; TRAIL-R2; TRAIL receptor 2; TRICKB; ZTNFR9 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Buffer | BBS (pH 8.2) |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # O14763 Human Tumor necrosis factor receptor superfamily member 10B |
|---|---|
| Gene Symbol | TNFRSF10B |
| Gene Full Name | tumor necrosis factor receptor superfamily, member 10b |
| Background | The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq, Mar 2009] |
| Function | Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis. [UniProt] |
| Calculated MW | 48 kDa |
Images (3) Click the Picture to Zoom In
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ARG22343 anti-CD262 / TRAIL R2 antibody ICC/IF image
Immunofluorescence: Human hepatocellular carcinoma cell line HepG2 stained with Rabbit IgG isotype control (left) and ARG22343 anti-CD262 / TRAIL R2 antibody (right) followed by ARG21782 Donkey anti-Rabbit IgG (H+L) antibody (Biotin) (pre-adsorbed), Streptavidin (Cy3) and DAPI.
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ARG22343 anti-CD262 / TRAIL R2 antibody WB image
Western blot: Jurkat cell lysate stained with ARG22343 anti-CD262 / TRAIL R2 antibody. Secondary antibody: ARG23768 Goat anti-Rabbit IgG (H+L) antibody (HRP) (pre-adsorbed).
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ARG22343 anti-CD262 / TRAIL R2 antibody FACS image
Flow Cytometry: Human T cell leukemia cell line Jurkat was stained with ARG22343 anti-CD262 / TRAIL R2 antibody followed by ARG23752 Mouse anti-Rabbit IgG antibody [2A9] (PE).
