ARG45080
anti-CD230 / Prion protein Phospho (Ser43) antibody
anti-CD230 / Prion protein Phospho (Ser43) antibody for Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes CD230 / Prion protein Phospho (Ser43) |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | CD230 / Prion protein |
| Antigen Species | Human |
| Immunogen | Prion Protein (Ser-43) antibody was generated from a phospho-peptide that included amino acids surrounding Serine 43 in human prion protein. This sequence has high homology to the conserved site in rat, mouse, and bovine prion protein. |
| Conjugation | Un-conjugated |
| Alternate Names | PRNP; Prion Protein (Kanno Blood Group); AltPrP; PRP ; CD230; PRIP; Alternative Prion Protein; Major Prion Protein; Prion Protein; CD230 Antigen; PrP33-35C; PrP27-30; P27-30; ASCR; CJD; GSS; Gerstmann-Strausler-Scheinker Syndrome; Creutzfeldt-Jakob Disease; Fatal Familial Insomnia; Prion Protein (P27-30); Prion-Related Protein; ALTPRP; KURU; PrPc; PrP |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Antigen Affinity Purified. |
| Buffer | PBS, 0.05% NaN3, 50% Glycerol and 0.1 % BSA. |
| Stabilizer | 50% Glycerol and 0.1 % BSA |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | PRNP |
| Gene Full Name | Prion Protein (Kanno Blood Group) |
| Background | The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. An overlapping open reading frame has been found for this gene that encodes a smaller, structurally unrelated protein, AltPrp. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014] |
| Function | Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu2+ or Zn2+ for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains. [Uniprot] |
| Cellular Localization | Amyloid, Cell membrane, Golgi apparatus, Membrane. [Uniprot] |
| Calculated MW | 28 kDa |
| PTM | Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein. [Uniprot] |
