ARG23441
anti-CD226 antibody [DX11] (PE)
anti-CD226 antibody [DX11] (PE) for Flow cytometry and Human
Immune System antibody; T Cell Intercellular Adhesion Molecule antibody
Overview
| Product Description | PE-conjugated Mouse Monoclonal antibody [DX11] recognizes CD226 Mouse anti Human CD226 antibody, clone DX11 recognizes human CD226, a ~65 kDa glycoprotein, also known as DNAM1 (DNAX accessory molecule-1). CD226 is broadly expressed on T-cells, NK cells, platelets, monocytes and a subset of B cells. CD226 is also expressed by a subset of CD3 positive thymocytes.Mouse anti Human CD226 antibody, clone DX11 is reported to inhibit T- and NK cell mediated cytotoxicity against tumor cell targets and to block TNF alpha and IFN gamma secretion by alloantigen-specific T-cells (Kojima et al. 2003). |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | FACS |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | DX11 |
| Isotype | IgG1 |
| Target Name | CD226 |
| Antigen Species | Human |
| Immunogen | Human cytotoxic T lymphocyte clone. |
| Conjugation | PE |
| Alternate Names | TLiSA1; CD antigen CD226; PTA1; CD226 antigen; DNAM-1; DNAX accessory molecule 1; DNAM1 |
Application Instructions
| Application Suggestion |
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| Application Note | FACS: Use 10 µl of the suggested working dilution to label 10^6 cells in 100 µl. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein A. |
| Buffer | PBS, 0.09% Sodium azide, 1% BSA and 5% Sucrose. |
| Preservative | 0.09% Sodium azide |
| Stabilizer | 1% BSA and 5% Sucrose |
| Storage Instruction | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | CD226 |
| Gene Full Name | CD226 molecule |
| Background | This gene encodes a glycoprotein expressed on the surface of NK cells, platelets, monocytes and a subset of T cells. It is a member of the Ig-superfamily containing 2 Ig-like domains of the V-set. The protein mediates cellular adhesion of platelets and megakaryocytic cells to vascular endothelial cells. The protein also plays a role in megakaryocytic cell maturation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015] |
| Function | Receptor involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell. [UniProt] |
| Research Area | Immune System antibody; T Cell Intercellular Adhesion Molecule antibody |
| Calculated MW | 39 kDa |
Images (1) Click the Picture to Zoom In
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ARG23441 anti-CD226 antibody [DX11] (PE) FACS image
Flow Cytometry: Figure A. FITC conjugated Mouse anti Human CD19 and PE-conjugated Mouse IgG1 isotype control. Figure B. FITC conjugated Mouse anti Human CD19 and ARG23441 anti-CD226 antibody [DX11] (PE). All experiments performed on red cell lysed Human peripheral blood gated on lymphocytes.
