ARG23440
anti-CD226 antibody [DX11]
anti-CD226 antibody [DX11] for CyTOF®-candidate,Flow cytometry,Immunoprecipitation and Human
Immune System antibody; T Cell Intercellular Adhesion Molecule antibody
Overview
Product Description | Mouse Monoclonal antibody [DX11] recognizes CD226 Mouse anti Human CD226 antibody, clone DX11 recognizes human CD226, a ~65 kDa glycoprotein, also known as DNAM1 (DNAX accessory molecule-1). CD226 is broadly expressed on T-cells, NK cells, platelets, monocytes and a subset of B cells. CD226 is also expressed by a subset of CD3 positive thymocytes.Mouse anti Human CD226 antibody, clone DX11 is reported to inhibit T- and NK cell mediated cytotoxicity against tumor cell targets and to block TNF alpha and IFN gamma secretion by alloantigen-specific T-cells (Kojima et al. 2003). |
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Tested Reactivity | Hu |
Tested Application | CyTOF®-candidate, FACS, IP |
Host | Mouse |
Clonality | Monoclonal |
Clone | DX11 |
Isotype | IgG1 |
Target Name | CD226 |
Antigen Species | Human |
Immunogen | Human cytotoxic T lymphocyte clone. |
Conjugation | Un-conjugated |
Alternate Names | TLiSA1; CD antigen CD226; PTA1; CD226 antigen; DNAM-1; DNAX accessory molecule 1; DNAM1 |
Application Instructions
Application Suggestion |
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Application Note | FACS: Use 10 µl of the suggested working dilution to label 10^6 cells in 100 µl. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
Form | Liquid |
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Purification | Purification with Protein G. |
Buffer | PBS and 0.09% Sodium azide. |
Preservative | 0.09% Sodium azide |
Concentration | 1 mg/ml |
Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
Database Links | |
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Gene Symbol | CD226 |
Gene Full Name | CD226 molecule |
Background | This gene encodes a glycoprotein expressed on the surface of NK cells, platelets, monocytes and a subset of T cells. It is a member of the Ig-superfamily containing 2 Ig-like domains of the V-set. The protein mediates cellular adhesion of platelets and megakaryocytic cells to vascular endothelial cells. The protein also plays a role in megakaryocytic cell maturation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015] |
Function | Receptor involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell. [UniProt] |
Highlight | Related products: CD226 antibodies; CD226 Duos / Panels; Anti-Mouse IgG secondary antibodies; Related news: CyTOF-candidate Antibodies |
Research Area | Immune System antibody; T Cell Intercellular Adhesion Molecule antibody |
Calculated MW | 39 kDa |