ARG59260
anti-CD201 / EPCR antibody
anti-CD201 / EPCR antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes CD201 / EPCR |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | CD201 / EPCR |
| Antigen Species | Human |
| Immunogen | Recombinant fusion protein corresponding to aa. 19-209 of Human CD201 / EPCR (NP_006395.2). |
| Conjugation | Un-conjugated |
| Alternate Names | CD antigen CD201; Activated protein C receptor; EPCR; APC receptor; CCCA; Endothelial cell protein C receptor; CCD41; Endothelial protein C receptor |
Application Instructions
| Predict Reactivity Note | Mouse | ||||||
|---|---|---|---|---|---|---|---|
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Positive Control | THP-1 | ||||||
| Observed Size | 50 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | PROCR |
| Gene Full Name | protein C receptor, endothelial |
| Background | The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy. The encoded protein may also play a role in malarial infection and has been associated with cancer. [provided by RefSeq, Jul 2013] |
| Function | Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation. [UniProt] |
| Cellular Localization | Membrane; Single-pass type I membrane protein. [UniProt] |
| Calculated MW | 27 kDa |
| PTM | N-glycosylated. A soluble form exists; probably released by a metalloprotease. Seems to have the same activity as the membrane-bound form. [UniProt] |
Images (2) Click the Picture to Zoom In
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ARG59260 anti-CD201 / EPCR antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Rat liver stained with ARG59260 anti-CD201 / EPCR antibody at 1:200 dilution.
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ARG59260 anti-CD201 / EPCR antibody WB image
Western blot: 25 µg of THP-1 cell lysate stained with ARG59260 anti-CD201 / EPCR antibody at 1:1000 dilution.
