ARG62761
anti-CD1a antibody [HI149]
anti-CD1a antibody [HI149] for CyTOF®-candidate,Flow cytometry,IHC-Frozen sections and Human
Immune System antibody
Overview
| Product Description | Mouse Monoclonal antibody [HI149] recognizes CD1a |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | CyTOF®-candidate, FACS, IHC-Fr |
| Specificity | The clone HI149 reacts with CD1a (T6), a 49 kDa polypeptide associated with beta2-microglobulin expressed on cortical thymocytes (strongly), Langerhans cells, dendritic cells and some T cell leukemias and lymphomas. does not react with peripheral blood T and B lymphocytes, monocytes, granulocytes, platelets and erythrocytes. HLDA V; WS Code CD01.01 |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | HI149 |
| Isotype | IgG1 |
| Target Name | CD1a |
| Antigen Species | Human |
| Immunogen | Human thymocytes |
| Conjugation | Un-conjugated |
| Alternate Names | R4; FCB6; CD antigen CD1a; T6; T-cell surface antigen T6/Leu-6; hTa1 thymocyte antigen; T-cell surface glycoprotein CD1a; CD1; HTA1 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purified by protein A |
| Purity | > 95% (by SDS-PAGE) |
| Buffer | PBS (pH 7.4) and 15 mM Sodium azide |
| Preservative | 15 mM Sodium azide |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | CD1A |
| Gene Full Name | CD1a molecule |
| Background | CD1a, together with CD1b and c, belongs to group 1 of CD1 glycoproteins. These proteins serve as antigen-presenting molecules for a subset of T cells that responds to specific lipids and glycolipids found in the cell walls of bacterial pathogens or self-glycolipid antigens such as gangliosides, and they have also roles in antiviral immunity. Unlike CD1b, CD1a is excluded from late endosomal compartments and instead traffics independently in the recycling pathway of the early endocytic system, and CD1a antigen presentation is independent upon vesicular acidification. |
| Function | Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells. [UniProt] |
| Highlight | Related products: CD1a antibodies; Anti-Mouse IgG secondary antibodies; Related news: CyTOF-candidate Antibodies Detecting exosomal HMGB1 for ICD research |
| Research Area | Immune System antibody |
| Calculated MW | 37 kDa |
