ARG43889
anti-CD194 / CCR4 antibody
anti-CD194 / CCR4 antibody for ELISA,Flow cytometry,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes CD194 / CCR4 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | ELISA, FACS, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Target Name | CD194 / CCR4 |
| Antigen Species | Human |
| Immunogen | Human CCR4 recombinant protein |
| Expression System | E.coli |
| Conjugation | Un-conjugated |
| Protein Full Name | C-C chemokine receptor type 4 |
| Alternate Names | CD194; ChemR13; K5-5; C-C chemokine receptor type 4; CCR-4; HGCN:14099; CKR4; CD antigen CD194; CC-CKR-4; CCR4; C-C CKR-4; CMKBR4 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Buffer | 0.9% NaCl, 0.2% Na2HPO4 and 4% Trehalose. |
| Stabilizer | 4% Trehalose |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | CCR4 |
| Gene Full Name | C-C Motif Chemokine Receptor 4 |
| Background | The protein encoded by this gene belongs to the G-protein-coupled receptor family . It is a receptor for the CC chemokine - MIP-1, RANTES, TARC and MCP-1. Chemokines are a group of small polypeptide, structurally related molecules that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. |
| Function | High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival. |
| Cellular Localization | Cell membrane |
| Calculated MW | 41 kDa |
| PTM | Disulfide bond, Glycoprotein, Phosphoprotein |
Images (4) Click the Picture to Zoom In
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ARG43889 anti-CD194 / CCR4 antibody WB image
Western blot: 293T and Raji stained with ARG43889 anti-CD194 / CCR4 antibody at 0.5 μg/mL dilution.
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ARG43889 anti-CD194 / CCR4 antibody FACS image
Flow Cytometry: HEL cells stained with ARG43889 anti-CD194 / CCR4 antibody (blue) at 1 μg/1x10^6 cells dilution.
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ARG43889 anti-CD194 / CCR4 antibody WB image
Western blot: Rat spleen and Rat thymus with ARG43889 anti-CD194 / CCR4 antibody at 0.5 μg/mL dilution.
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ARG43889 anti-CD194 / CCR4 antibody WB image
Western blot: Mouse spleen and Mouse thymus with ARG43889 anti-CD194 / CCR4 antibody at 0.5 μg/mL dilution.
