ARG59880
anti-CD192 / CCR2 antibody
anti-CD192 / CCR2 antibody for Flow cytometry,IHC-Formalin-fixed paraffin-embedded sections and Human,Mouse
Overview
| Product Description | Rabbit Polyclonal antibody recognizes CD192 / CCR2 |
|---|---|
| Tested Reactivity | Hu, Ms |
| Tested Application | FACS, IHC-P |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | CD192 / CCR2 |
| Antigen Species | Human |
| Immunogen | Synthetic peptide derived from Human CD192 / CCR2. |
| Conjugation | Un-conjugated |
| Alternate Names | CCR2B; CD192; CKR2; Monocyte chemoattractant protein 1 receptor; CCR-2; CKR2B; CKR2A; CMKBR2; CCR2; C-C CKR-2; CC-CKR-2; CD antigen CD192; MCP-1-R; CCR2A; C-C chemokine receptor type 2 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.4), 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | CCR2 |
| Gene Full Name | chemokine (C-C motif) receptor 2 |
| Background | This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This gene is located in the chemokine receptor gene cluster region. Two alternatively spliced transcript variants are expressed by the gene. [provided by RefSeq, Mar 2009] |
| Function | Receptor for the CCL2, CCL7 and CCL13 chemokines. Transduces a signal by increasing intracellular calcium ion levels. Alternative coreceptor with CD4 for HIV-1 infection. [UniProt] |
| Cellular Localization | Cell membrane; Multi-pass membrane protein. Note=The chemoattractant receptors are distributed throughout the cell surface; after stimulation with a ligand, such as CCL2, they are rapidly recruited into microdomain clusters at the cell membrane. [UniProt] |
| Calculated MW | 42 kDa |
| PTM | N-glycosylated. Sulfation increases the affinity for both monomeric and dimeric CCL2 with stronger binding to the monomeric form. Binding of sulfated CCR2 to CCL2 promotes conversion of CCL2 from dimer to monomer. [UniProt] |
Images (1) Click the Picture to Zoom In
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ARG59880 anti-CD192 / CCR2 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human tonsil stained with ARG59880 anti-CD192 / CCR2 antibody.
