ARG22871
anti-CD169 / Siglec 1 antibody [3D6.112] (FITC)
anti-CD169 / Siglec 1 antibody [3D6.112] (FITC) for Flow cytometry and Mouse
Overview
| Product Description | FITC-conjugated Rat Monoclonal antibody [3D6.112] recognizes CD169 / Siglec 1 |
|---|---|
| Tested Reactivity | Ms |
| Tested Application | FACS |
| Host | Rat |
| Clonality | Monoclonal |
| Clone | 3D6.112 |
| Isotype | IgG2a |
| Target Name | CD169 / Siglec 1 |
| Antigen Species | Mouse |
| Immunogen | Purified murine sialoadhesin. |
| Conjugation | FITC |
| Alternate Names | CD169; Siglec-1; dJ1009E24.1; Sialic acid-binding Ig-like lectin 1; SIGLEC-1; CD antigen CD169; SN; Sialoadhesin |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein G. |
| Buffer | PBS, 0.09% Sodium azide and 1% BSA |
| Preservative | 0.09% Sodium azide |
| Stabilizer | 1% BSA |
| Concentration | 0.1 mg/ml |
| Storage Instruction | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | Siglec1 |
| Gene Full Name | sialic acid binding Ig-like lectin 1, sialoadhesin |
| Background | This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a lectin-like adhesion molecule that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I transmembrane protein expressed only by a subpopulation of macrophages and is involved in mediating cell-cell interactions. Alternative splicing produces a transcript variant encoding an isoform that is soluble rather than membrane-bound; however, the full-length nature of this variant has not been determined. [provided by RefSeq, Jul 2008] |
| Function | Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Preferentially binds to alpha-2,3-linked sialic acid (By similarity). Binds to SPN/CD43 on T-cells (By similarity). May play a role in hemopoiesis. [UniProt] |
| Calculated MW | 183 kDa |
Images (1) Click the Picture to Zoom In
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ARG22871 anti-CD169 / Siglec 1 antibody [3D6.112] (FITC) FACS image
Flow Cytometry: Figure A. RPE conjugated Rat anti Mouse CD45R and FITC conjugated Rat IgG2a isotype control. Figure B. RPE conjugated Rat anti Mouse CD45R and ARG22871 anti-CD169 / Siglec 1 antibody [3D6.112] (FITC). All experiments performed on murine bone marrow.
