ARG23097
anti-CD134 / OX40 antibody [OX-40]
anti-CD134 / OX40 antibody [OX-40] for Flow cytometry,IHC-Frozen sections,Immunoprecipitation and Rat
Overview
| Product Description | Mouse Monoclonal antibody [OX-40] recognizes CD134 / OX40. Mouse anti Rat CD134 antibody, clone OX-40 recognizes the OX40 antigen which is present on activated T lymphocytes that also express CD4 (Paterson et al. 1987).The antigen is a glycoprotein of approximately 50 kDa which is related in sequence to the low affinity Nerve Growth Factor Receptor (Mallett et al. 1990).Mouse anti Rat CD134 antibody, clone OX-40 is not mitogenic, but does enhance some T cell responses (Paterson et al. 1987). |
|---|---|
| Tested Reactivity | Rat |
| Tested Application | FACS, IHC-Fr, IP |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | OX-40 |
| Isotype | IgG2b |
| Target Name | CD134 / OX40 |
| Antigen Species | Rat |
| Immunogen | Phytohemagglutinin (PHA) activated Rat Lymph Node Cells. |
| Conjugation | Un-conjugated |
| Alternate Names | CD134; TAX transcriptionally-activated glycoprotein 1 receptor; TXGP1L; OX40L receptor; Tumor necrosis factor receptor superfamily member 4; OX40; CD antigen CD134; IMD16; ACT35 antigen; ACT35 |
Application Instructions
| Application Suggestion |
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| Application Note | FACS: Use 10 µl of the suggested working dilution to label 10^6 cells in 100 µl. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein G. |
| Buffer | PBS and 0.09% Sodium azide |
| Preservative | 0.09% Sodium azide |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # P15725 Rat Tumor necrosis factor receptor superfamily member 4 |
|---|---|
| Gene Symbol | Tnfrsf4 |
| Gene Full Name | tumor necrosis factor receptor superfamily, member 4 |
| Background | The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [provided by RefSeq, Jul 2008] |
| Function | Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity. [UniProt] |
| Calculated MW | 29 kDa |
