ARG59570
anti-CD121a / IL1 Receptor1 antibody
anti-CD121a / IL1 Receptor1 antibody for Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes CD121a / IL1 Receptor1 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | CD121a / IL1 Receptor1 |
| Antigen Species | Human |
| Immunogen | Recombinant protein of Human CD121a / IL1 Receptor1 |
| Conjugation | Un-conjugated |
| Alternate Names | Interleukin-1 receptor alpha; sIL-1R1; p80; CD121A; mIL-1RI; IL1R; P80; Interleukin-1 receptor type I; IL1RA; D2S1473; Interleukin-1 receptor type 1; IL-1R-alpha; IL-1RT-1; CD121 antigen-like family member A; IL-1R-1; sIL-1RI; IL-1RT1; mIL-1R1; CD antigen CD121a |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| Positive Control | BT-474 | ||||
| Observed Size | 80 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | IL1R1 |
| Gene Full Name | interleukin 1 receptor, type I |
| Background | This gene encodes a cytokine receptor that belongs to the interleukin-1 receptor family. The encoded protein is a receptor for interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist. It is an important mediator involved in many cytokine-induced immune and inflammatory responses. This gene is located in a cluster of related cytokine receptor genes on chromosome 2q12. [provided by RefSeq, Dec 2013] |
| Function | Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. [UniProt] |
| Cellular Localization | Membrane; Single-pass type I membrane protein. Cell membrane. Secreted. [UniProt] |
| Calculated MW | 65 kDa |
| PTM | A soluble form (sIL1R1) is probably produced by proteolytic cleavage at the cell surface (shedding). Rapidly phosphorylated on Tyr-496 in response to IL-1, which creates a SH2 binding site for the PI 3-kinase regulatory subunit PIK3R1. [UniProt] |
Images (1) Click the Picture to Zoom In
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ARG59570 anti-CD121a / IL1 Receptor1 antibody WB image
Western blot: 25 µg of BT-474 cell lysate stained with ARG59570 anti-CD121a / IL1 Receptor1 antibody at 1:1000 dilution.
