ARG22081
anti-CD103 / Integrin alpha E antibody [2E7]
anti-CD103 / Integrin alpha E antibody [2E7] for Cellular activation ,Flow cytometry,IHC-Frozen sections,Immunoprecipitation and Mouse
Overview
| Product Description | Hamster Monoclonal antibody [2E7] recognizes CD103 / Integrin alpha E |
|---|---|
| Tested Reactivity | Ms |
| Tested Application | Cell-Act , FACS, IHC-Fr, IP |
| Specificity | Mouse CD103 |
| Host | Hamster |
| Clonality | Monoclonal |
| Clone | 2E7 |
| Isotype | IgG2 |
| Target Name | CD103 / Integrin alpha E |
| Antigen Species | Mouse |
| Immunogen | C57BL/6J Mouse intestinal intraepithelial lymphocytes (IEL) |
| Conjugation | Un-conjugated |
| Alternate Names | CD103; HUMINAE; Integrin alpha-E; Mucosal lymphocyte 1 antigen; CD antigen CD103; HML-1 antigen; Integrin alpha-IEL |
Application Instructions
| Application Suggestion |
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|---|---|---|---|---|---|---|---|---|---|---|---|
| Application Note | Cellular activation: This clone up-regulates CD5 surface expression on CD8 alpha/beta+ gut IEL cells (gut intraepithelial lymphocytes) * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Buffer | BBS (pH 8.2) |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | ITGAE |
| Gene Full Name | integrin alpha E, epithelial-associated |
| Background | Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation. [provided by RefSeq, Jul 2008] |
| Function | Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers. [UniProt] |
| Calculated MW | 130 kDa |
