ARG45339
anti-CCRL-2 antibody [5A15]
anti-CCRL-2 antibody [5A15] for IHC-Formalin-fixed paraffin-embedded sections and Human
Overview
| Product Description | Mouse Monoclonal antibody [5A15] recognizes CCRL-2 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IHC-P |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 5A15 |
| Isotype | IgG2 |
| Target Name | CCRL-2 |
| Antigen Species | Human |
| Immunogen | Recombinant Human CCRL-2. |
| Conjugation | Un-conjugated |
| Alternate Names | CCRL2; C-C Motif Chemokine Receptor Like 2; CKRX; HCR; CRAM-B; CRAM-A; ACKR5; Chemokine (C-C Motif) Receptor-Like 2; Putative MCP-1 Chemokine Receptor; Atypical Chemokine Receptor 5; C-C Chemokine Receptor-Like 2; Chemokine Receptor CCR11; Chemokine Receptor X; CRAM; CCR11; CCR6 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Protein G chromatography |
| Buffer | PBS |
| Concentration | 0.2 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | CCRL2 |
| Gene Full Name | C-C Motif Chemokine Receptor Like 2 |
| Background | This gene encodes a chemokine receptor like protein, which is predicted to be a seven transmembrane protein and most closely related to CCR1. Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. This gene is expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. The function of this gene is unknown. This gene is mapped to the region where the chemokine receptor gene cluster is located. [provided by RefSeq, Jul 2008] |
| Function | Receptor for CCL19 and chemerin/RARRES2. Does not appear to be a signaling receptor, but may have a role in modulating chemokine-triggered immune responses by capturing and internalizing CCL19 or by presenting RARRES2 ligand to CMKLR1, a functional signaling receptors. Plays a critical role for the development of Th2 responses. [UniProt] |
| Cellular Localization | Cell membrane; Membrane. [UniProt] |
| Calculated MW | 40 kDa |
| PTM | Disulfide bond; Glycoprotein. [UniProt] |
Images (1) Click the Picture to Zoom In
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ARG45339 anti-CCRL-2 antibody [5A15] IHC-P image
Immunohistochemistry: Human placental stained with ARG45339 anti-CCRL-2 antibody [5A15].
