ARG56596
anti-CCL3 / MIP1 alpha antibody [1.2_3E8-2H6-2B6]
anti-CCL3 / MIP1 alpha antibody [1.2_3E8-2H6-2B6] for ELISA,Neutralizing,Western blot and Human
Overview
| Product Description | Mouse Monoclonal antibody [1.2_3E8-2H6-2B6] recognizes CCL3 / MIP1 alpha |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | ELISA, Neut, WB |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 1.2_3E8-2H6-2B6 |
| Isotype | IgG1, kappa |
| Target Name | CCL3 / MIP1 alpha |
| Antigen Species | Human |
| Immunogen | E.coli derived Recombinant Human MIP-1α (CCL3). (ASLAADTPTA CCFSYTSRQI PQNFIADYFE TSSQCSKPGV IFLTKRSRQV CADPSEEWVQ KYVSDLELSA) |
| Conjugation | Un-conjugated |
| Alternate Names | MIP-1-alpha; SIS-beta; PAT 464.1; Tonsillar lymphocyte LD78 alpha protein; G0/G1 switch regulatory protein 19-1; Small-inducible cytokine A3; C-C motif chemokine 3; LD78-alpha; 4-69; Macrophage inflammatory protein 1-alpha; MIP1A; SCYA3; G0S19-1; LD78ALPHA |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein G. |
| Buffer | PBS (pH 7.2) |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | CCL3 |
| Gene Full Name | chemokine (C-C motif) ligand 3 |
| Background | This locus represents a small inducible cytokine. The encoded protein, also known as macrophage inflammatory protein 1 alpha, plays a role in inflammatory responses through binding to the receptors CCR1, CCR4 and CCR5. Polymorphisms at this locus may be associated with both resistance and susceptibility to infection by human immunodeficiency virus type 1.[provided by RefSeq, Sep 2010] |
| Function | Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). [UniProt] |
| Calculated MW | 10 kDa |
| PTM | N-terminal processed form LD78-alpha(4-69) is produced by proteolytic cleavage after secretion from HTLV1-transformed T-cells. |
Images (1) Click the Picture to Zoom In
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ARG56596 anti-CCL3 / MIP1 alpha antibody [1.2_3E8-2H6-2B6] standard curve image
Sandwich ELISA: ARG56596 anti-CCL3 / MIP1 alpha antibody [1.2_3E8-2H6-2B6] as a capture antibody at 2.0 - 4.0 µg/ml combined with ARG56761 anti-MIP1 alpha / CCL3 antibody (Biotin) as a detection antibody at ~ 1.0 - 2.0 µg/ml. Results of a typical standard run with optical density.
