ARG56634
anti-CCL21 / Exodus 2 antibody
anti-CCL21 / Exodus 2 antibody for ELISA,Neutralizing,Western blot and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes CCL21 / Exodus 2 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | ELISA, Neut, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | CCL21 / Exodus 2 |
| Antigen Species | Human |
| Immunogen | E.coli derived Recombinant Human Exodus2. (SDGGAQDCCL KYSQRKIPAK VVRSYRKQEP SLGCSIPAIL FLPRKRSQAE LCADPKELWV QQLMQHLDKT PSPQKPAQGC RKDRGASKTG KKGKGSKGCR KTERSQTPKG P) |
| Conjugation | Un-conjugated |
| Alternate Names | TCA4; Small-inducible cytokine A21; Beta-chemokine exodus-2; ECL; SCYA21; Secondary lymphoid-tissue chemokine; CKb9; 6Ckine; C-C motif chemokine 21; SLC |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | PBS (pH 7.2) |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | CCL21 |
| Gene Full Name | chemokine (C-C motif) ligand 21 |
| Background | This antimicrobial gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. Similar to other chemokines the protein encoded by this gene inhibits hemopoiesis and stimulates chemotaxis. This protein is chemotactic in vitro for thymocytes and activated T cells, but not for B cells, macrophages, or neutrophils. The cytokine encoded by this gene may also play a role in mediating homing of lymphocytes to secondary lymphoid organs. It is a high affinity functional ligand for chemokine receptor 7 that is expressed on T and B lymphocytes and a known receptor for another member of the cytokine family (small inducible cytokine A19). [provided by RefSeq, Sep 2014] |
| Function | Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4. [UniProt] |
| Calculated MW | 15 kDa |
Images (5) Click the Picture to Zoom In
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ARG56634 anti-CCL21 / Exodus 2 antibody WB image
Western blot: 250 - 0.24 ng of Human Exodus-2 stained with ARG56634 anti-CCL21 / Exodus 2 antibody, under reducing conditions.
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ARG56634 anti-CCL21 / Exodus 2 antibody WB image
Western blot: 250 - 0.24 ng of Human Exodus-2 stained with ARG56634 anti-CCL21 / Exodus 2 antibody, under reducing conditions.
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ARG56634 anti-CCL21 / Exodus 2 antibody WB image
Western blot: 250 - 0.24 ng of Human Exodus-2 stained with ARG56634 anti-CCL21 / Exodus 2 antibody, under non-reducing conditions.
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ARG56634 anti-CCL21 / Exodus 2 antibody WB image
Western blot: 250 - 0.24 ng of Human Exodus-2 stained with ARG56634 anti-CCL21 / Exodus 2 antibody, under non-reducing conditions.
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ARG56634 anti-CCL21 / Exodus 2 antibody standard curve image
Sandwich ELISA: ARG56634 anti-CCL21 / Exodus 2 antibody as a capture antibody at 0.5 - 2.0 µg/ml combined with ARG56744 anti-CCL21 / Exodus2 antibody (Biotin) as a detection antibody. Results of a typical standard run with optical density.
