ARG43925
anti-Bcl 11B / Ctip2 antibody
anti-Bcl 11B / Ctip2 antibody for Flow cytometry,ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes Bcl 11B / Ctip2 |
|---|---|
| Tested Reactivity | Hu, Rat |
| Tested Application | FACS, ICC/IF, IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Target Name | Bcl 11B / Ctip2 |
| Antigen Species | Human |
| Immunogen | Human Bcl 11B / Ctip2 recombinant protein |
| Expression System | E.coli |
| Conjugation | Un-conjugated |
| Protein Full Name | B-cell lymphoma/leukemia 11B |
| Alternate Names | CL11B; BCL11 Transcription Factor B; CTIP2; BAF Chromatin Remodeling Complex Subunit BCL11B; HRIT1-Alpha; SMARCM2; CTIP-2; Radiation-Induced Tumor Suppressor Gene 1 Protein; B-Cell CLL/Lymphoma 11B (Zinc Finger Protein); BCL11B, BAF Complex Component; COUP-TF-Interacting Protein 2; B-Cell Lymphoma/Leukemia 11B; B Cell CLL/Lymphoma 11B; ZNF856B; BCL-11B; HRit1; RIT1; B-Cell CLL/Lymphoma 11B/T-Cell Receptor Delta Constant Region Fusion Protein; Zinc Finger Protein HRit1 Alpha; B-Cell Lymphoma/Leukaemia 11B; B-Cell CLL/Lymphoma 11B; BCL11B/TRDC Fusion; ATL1-Alpha; ATL1-Delta; ATL1-Gamma; ATL1-Beta; IDDFSTA; IMD49; ATL1 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Buffer | 0.9% NaCl, 0.2% Na2HPO4 and 4% Trehalose. |
| Stabilizer | 4% Trehalose |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | BCL11B |
| Gene Full Name | BCL11 Transcription Factor B |
| Background | This gene encodes a C2H2-type zinc finger protein and is closely related to BCL11A, a gene whose translocation may be associated with B-cell malignancies. Although the specific function of this gene has not been determined, the encoded protein is known to be a transcriptional repressor, and is regulated by the NURD nucleosome remodeling and histone deacetylase complex. Four alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. |
| Function | Key regulator of both differentiation and survival of T-lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of the receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus. |
| Cellular Localization | Nucleus |
| Calculated MW | 96 kDa |
| PTM | Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation |
Images (6) Click the Picture to Zoom In
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ARG43925 anti-Bcl 11B / Ctip2 antibody IHC-P image
Immunohistochemistry: Human breast cancer stained with ARG43925 anti-Bcl 11B / Ctip2 antibody at 2 μg/ml dilution.
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ARG43925 anti-Bcl 11B / Ctip2 antibody WB image
Western blot: MOLT-4 stained with ARG43925 anti-Bcl 11B / Ctip2 antibody at 0.5 μg/mL dilution.
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ARG43925 anti-Bcl 11B / Ctip2 antibody FACS image
Flow Cytometry: C6 cells stained with ARG43925 anti-Bcl 11B / Ctip2 antibody (blue) at 1 μg/1x10^6 cells dilution.
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ARG43925 anti-Bcl 11B / Ctip2 antibody ICC/IF image
Immunofluorescence: U2OS cells stained with ARG43925 anti-Bcl 11B / Ctip2 antibody at 5 μg/ml dilution.
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ARG43925 anti-Bcl 11B / Ctip2 antibody IHC-P image
Immunohistochemistry: Human lymph node metastasis carcinoma stained with ARG43925 anti-Bcl 11B / Ctip2 antibody at 2 μg/ml dilution.
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ARG43925 anti-Bcl 11B / Ctip2 antibody IHC-P image
Immunohistochemistry: Human placenta stained with ARG43925 anti-Bcl 11B / Ctip2 antibody at 2 μg/ml dilution.
