ARG45690
anti-BCCIP antibody
anti-BCCIP antibody for Flow cytometry,ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes BCCIP |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | FACS, ICC/IF, IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | BCCIP |
| Antigen Species | Human |
| Immunogen | Recombinant protein containing to human BCCIP. |
| Conjugation | Un-conjugated |
| Alternate Names | BCCIP; BRCA2 And CDKN1A Interacting Protein; BRCA2 And CDKN1A-Interacting Protein; BCCIPalpha; TOK-1; P21- And CDK-Associated Protein 1; Protein TOK-1; TOK1; BRCA2 And Cip1/P21 Interacting Protein; Cdk Inhibitor P21 Binding Protein; TOK-1alpha; BCCIPbeta; TOK-1beta |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||||
| Observed Size | 45 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified |
| Buffer | 0.2% Na2HPO4, 0.9% NaCl and 4% Trehalose. |
| Stabilizer | 4% Trehalose |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q9CWI3 Mouse BRCA2 and CDKN1A-interacting protein Swiss-port # Q9P287 Human BRCA2 and CDKN1A-interacting protein |
|---|---|
| Gene Symbol | BCCIP |
| Gene Full Name | BRCA2 And CDKN1A Interacting Protein |
| Background | This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] |
| Function | During interphase, required for microtubule organizing and anchoring activities. During mitosis, required for the organization and stabilization of the spindle pole. [UniProt] |
| Cellular Localization | Cytoplasm; Cytoskeleton; Nucleus. [UniProt] |
| Calculated MW | 36 kDa |
| PTM | Phosphoprotein. [UniProt] |
Images (5) Click the Picture to Zoom In
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ARG45690 anti-BCCIP antibody ICC/IF image
Immunofluorescence: A549 stained with ARG45690 anti-BCCIP antibody at 5 μg/ml dilution.
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ARG45690 anti-BCCIP antibody WB image
Western blot: A431 stained with ARG45690 anti-BCCIP antibody at 0.5 μg/ml dilution.
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ARG45690 anti-BCCIP antibody FACS image
Flow Cytometry: CACO-2 stained with ARG45690 anti-BCCIP antibody at 1 µg/10^6 cells dilution.
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ARG45690 anti-BCCIP antibody IHC-P image
Immunohistochemistry: Rat testis stained with ARG45690 anti-BCCIP antibody at 2 μg/ml dilution.
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ARG45690 anti-BCCIP antibody IHC-P image
Immunohistochemistry: Mouse liver stained with ARG45690 anti-BCCIP antibody at 2 μg/ml dilution.
