ARG57385
anti-BAZ1B / WSTF antibody
anti-BAZ1B / WSTF antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes BAZ1B / WSTF |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | BAZ1B / WSTF |
| Antigen Species | Human |
| Immunogen | Recombinant Protein of Human BAZ1B / WSTF. |
| Conjugation | Un-conjugated |
| Alternate Names | WSTF; WBSCR10; Williams-Beuren syndrome chromosomal region 9 protein; hWALp2; Bromodomain adjacent to zinc finger domain protein 1B; Williams-Beuren syndrome chromosomal region 10 protein; Williams syndrome transcription factor; Tyrosine-protein kinase BAZ1B; WBSCR9; EC 2.7.10.2 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Positive Control | HeLa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | BAZ1B |
| Gene Full Name | bromodomain adjacent to zinc finger domain, 1B |
| Background | This gene encodes a member of the bromodomain protein family. The bromodomain is a structural motif characteristic of proteins involved in chromatin-dependent regulation of transcription. This gene is deleted in Williams-Beuren syndrome, a developmental disorder caused by deletion of multiple genes at 7q11.23. [provided by RefSeq, Jul 2008] |
| Function | Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator. Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes. In the complex, it mediates the recruitment of the WICH complex to replication foci during DNA replication. [UniProt] |
| Calculated MW | 171 kDa |
Images (2) Click the Picture to Zoom In
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ARG57385 anti-BAZ1B / WSTF antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Mouse brain tissue stained with ARG57385 anti-BAZ1B / WSTF antibody at 1:100 dilution.
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ARG57385 anti-BAZ1B / WSTF antibody WB image
Western blot: HeLa cell lysate stained with ARG57385 anti-BAZ1B / WSTF antibody.
