ARG44736
anti-Antithrombin III antibody
anti-Antithrombin III antibody for Immunoprecipitation and Human
Overview
| Product Description | Mouse Monoclonal antibody recognizes Antithrombin III |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IP |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Target Name | Antithrombin III |
| Antigen Species | Human |
| Conjugation | Un-conjugated |
| Alternate Names | AT3D; Antithrombin-III; ATIII; Serpin C1; AT3; THPH7 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Protein A purification |
| Buffer | PBS with 0.09% sodium azide |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | SERPINC1 |
| Gene Full Name | serpin peptidase inhibitor, clade C (antithrombin), member 1 |
| Background | The protein encoded by this gene is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency. [provided by RefSeq, Jul 2009] |
| Function | Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin. [UniProt] |
| Cellular Localization | Secreted, extracellular space. |
Images (1) Click the Picture to Zoom In
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ARG44736 anti-Antithrombin III antibody IP image
Immunoprecipitation: Plasma lysate immunoprecipitated with 2.5 µg of ARG44736 anti-Antithrombin III antibody.
