ARG45393
anti-APOBEC3C antibody
anti-APOBEC3C antibody for Flow cytometry,ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes APOBEC3C |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | FACS, ICC/IF, IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | APOBEC3C |
| Antigen Species | Human |
| Immunogen | Synthetic peptide corresponding to N-terminal region of human APOBEC3C. |
| Conjugation | Un-conjugated |
| Alternate Names | ARDC4; ARDC2; Phorbolin I; bK150C2.3; A3C; APOBEC1-like; DNA dC->dU-editing enzyme APOBEC-3C; EC 3.5.4.-; ARP5; APOBEC1L; PBI |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||||
| Observed Size | 23 kDa |
Properties
| Form | Powder |
|---|---|
| Purification | Affinity purified |
| Buffer | 0.2% Na2HPO4, 0.9% NaCl and 4% Trehalose. |
| Stabilizer | 4% Trehalose |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q9NRW3 Human DNA dC->dU-editing enzyme APOBEC-3C |
|---|---|
| Gene Symbol | APOBEC3C |
| Gene Full Name | Apolipoprotein B MRNA Editing Enzyme Catalytic Subunit 3C |
| Background | This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. [provided by RefSeq, Jul 2008] |
| Function | DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity against simian immunodeficiency virus (SIV), hepatitis B virus (HBV), herpes simplex virus 1 (HHV-1) and Epstein-Barr virus (EBV) and may inhibit the mobility of LTR and non-LTR retrotransposons. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation. [UniProt] |
| Cellular Localization | Cytoplasm; Nucleus. [UniProt] |
| Calculated MW | 23 kDa |
Images (6) Click the Picture to Zoom In
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ARG45393 anti-APOBEC3C antibody IHC-P image
Immunohistochemistry: Human breast cancer stained with ARG45393 anti-APOBEC3C antibody at 2 μg/ml dilution.
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ARG45393 anti-APOBEC3C antibody ICC/IF image
Immunofluorescence: Hela stained with ARG45393 anti-APOBEC3C antibody at 5 μg/ml dilution.
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ARG45393 anti-APOBEC3C antibody WB image
Western blot: PC-3 and K562 stained with ARG45393 anti-APOBEC3C antibody at 0.5 μg/ml dilution.
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ARG45393 anti-APOBEC3C antibody FACS image
Flow Cytometry: K562 stained with ARG45393 anti-APOBEC3C antibody at 1 µg/10^6 cells dilution.
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ARG45393 anti-APOBEC3C antibody WB image
Western blot: Rat spleen stained with ARG45393 anti-APOBEC3C antibody at 0.5 μg/ml dilution.
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ARG45393 anti-APOBEC3C antibody WB image
Western blot: Mouse spleen stained with ARG45393 anti-APOBEC3C antibody at 0.5 μg/ml dilution.
