ARG23493
anti-ANP / Atrial Natriuretic Peptide antibody [23/1]
anti-ANP / Atrial Natriuretic Peptide antibody [23/1] for IHC-Formalin-fixed paraffin-embedded sections,Radioimmunoassay and Human
Overview
| Product Description | Mouse Monoclonal antibody [23/1] recognizes ANP / Atrial Natriuretic Peptide |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IHC-P, RIA |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 23/1 |
| Isotype | IgG1 |
| Target Name | ANP / Atrial Natriuretic Peptide |
| Antigen Species | Human |
| Immunogen | Synthetic peptide corresponding to part of the native molecule conjugated to BSA. |
| Conjugation | Un-conjugated |
| Alternate Names | CDD; Natriuretic peptides A; ANF; Cardiodilatin; Cardiodilatin-related peptide; Atrial natriuretic peptide; Prepronatriodilatin; ATFB6; CDP; ATRST2; ANP; CDD-ANF; PND |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein A. |
| Buffer | PBS and 0.1% Sodium azide. |
| Preservative | 0.1% Sodium azide |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | NPPA |
| Gene Full Name | natriuretic peptide A |
| Background | The protein encoded by this gene belongs to the natriuretic peptide family. Natriuretic peptides are implicated in the control of extracellular fluid volume and electrolyte homeostasis. This protein is synthesized as a large precursor (containing a signal peptide), which is processed to release a peptide from the N-terminus with similarity to vasoactive peptide, cardiodilatin, and another peptide from the C-terminus with natriuretic-diuretic activity. Mutations in this gene have been associated with atrial fibrillation familial type 6. [provided by RefSeq, Sep 2009] |
| Function | Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3. [UniProt] |
| Calculated MW | 16 kDa |
| PTM | Cleaved by CORIN upon secretion to produce the functional hormone. Atrial natriuretic factor: Cleaved by MME. The cleavage initiates degradation of the factor and thereby regulate its activity. [UniProt] |
