ARG40837
anti-AKR1C1 + AKR1C2 antibody
anti-AKR1C1 + AKR1C2 antibody for Western blot and Human,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes AKR1C1 + AKR1C2 |
|---|---|
| Tested Reactivity | Hu, Rat |
| Tested Application | WB |
| Specificity | This antibody might also react to AKR1C3 and AKR1C4 based on sequence homology analysis (> 80%). |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | AKR1C1 + AKR1C2 |
| Antigen Species | Human |
| Immunogen | Recombinant protein corresponding to M1-K123 of Human AKR1C1/C2. |
| Conjugation | Un-conjugated |
| Alternate Names | Chlordecone reductase homolog HAKRD; Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; MCDR2; DD; SRXY8; DD/BABP; Dihydrodiol dehydrogenase 2; EC 1.-.-.-; DD2; HBAB; Dihydrodiol dehydrogenase/bile acid-binding protein; Aldo-keto reductase family 1 member C2; 3-alpha-HSD3; DDH2; EC 1.3.1.20; EC 1.1.1.357; BABP; Type III 3-alpha-hydroxysteroid dehydrogenase; AKR1C-pseudo; DD-2; TDD; HAKRD |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | 0.2% Na2HPO4, 0.9% NaCl, 0.05% Sodium azide and 5% BSA. |
| Preservative | 0.05% Sodium azide |
| Stabilizer | 5% BSA |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # P52895 Human Aldo-keto reductase family 1 member C2 Swiss-port # Q6AYQ2 Rat Aldo-keto reductase family 1 member C21 |
|---|---|
| Gene Symbol | AKR1C2 |
| Gene Full Name | aldo-keto reductase family 1, member C2 |
| Background | This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Dec 2011] |
| Function | Works in concert with the 5-alpha/5-beta-steroid reductases to convert steroid hormones into the 3-alpha/5-alpha and 3-alpha/5-beta-tetrahydrosteroids. Catalyzes the inactivation of the most potent androgen 5-alpha-dihydrotestosterone (5-alpha-DHT) to 5-alpha-androstane-3-alpha,17-beta-diol (3-alpha-diol). Has a high bile-binding ability. [UniProt] |
| Cellular Localization | Cytoplasm. [UniProt] |
| Calculated MW | 37 kDa |
Images (1) Click the Picture to Zoom In
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ARG40837 anti-AKR1C1 + AKR1C2 antibody WB image
Western blot: Rat liver and HeLa whole cell lysates stained with ARG40837 anti-AKR1C1 + AKR1C2 antibody at 0.5 µg/ml dilution.
