ARG55895
anti-AGTR1 / AT1 antibody
anti-AGTR1 / AT1 antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse
Overview
| Product Description | Rabbit Polyclonal antibody recognizes AGTR1 |
|---|---|
| Tested Reactivity | Hu, Ms |
| Predict Reactivity | Rat |
| Tested Application | ICC/IF, IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | AGTR1 / AT1 |
| Antigen Species | Human |
| Immunogen | Synthetic peptide (16 aa) within aa. 210-260 of Human AGTR1. |
| Conjugation | Un-conjugated |
| Alternate Names | AT1AR; Angiotensin II type-1 receptor; AT1R; Type-1 angiotensin II receptor; AT1BR; AG2S; AT2R1; HAT1R; AT1; AGTR1B; AT1B |
Application Instructions
| Application Suggestion |
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| Application Note | The dilutions for rat samples might have to be optimized by end user. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
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| Positive Control | Mouse kidney tissue lysate |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | PBS and 0.02% Sodium azide |
| Preservative | 0.02% Sodium azide |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | AGTR1 |
| Gene Full Name | angiotensin II receptor, type 1 |
| Background | Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. Multiple alternatively spliced transcript variants have been reported for this gene. [provided by RefSeq, Jul 2012] |
| Function | Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. [UniProt] |
| Calculated MW | 41 kDa |
| PTM | C-terminal Ser or Thr residues may be phosphorylated. |
Images (4) Click the Picture to Zoom In
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ARG55895 anti-AGTR1 / AT1 antibody WB image
Western blot: Mouse kidney tissue lysate stained with ARG55895 anti-AGTR1 / AT1 antibody at (A) 1 and (B) 2 µg/ml dilution.
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ARG55895 anti-AGTR1 / AT1 antibody IHC-P image
Immunohistochemistry: Mouse kidney tissue stained with ARG55895 anti-AGTR1 / AT1 antibody at 2.5 µg/ml dilution.
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ARG55895 anti-AGTR1 / AT1 antibody IF image
Immunofluorescence: Mouse Kidney cells stained with ARG55895 anti-AGTR1 / AT1 antibody at 20 µg/ml dilution.
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ARG55895 anti-AGTR1 / AT1 antibody IHC-P image
Immunohistochemistry: Mouse kidney tissue stained with ARG55895 anti-AGTR1 / AT1 antibody at 2.5 µg/ml dilution.
