ARG45333
anti-AGRP / Agouti related protein antibody [32B12]
anti-AGRP / Agouti related protein antibody [32B12] for IHC-Formalin-fixed paraffin-embedded sections and Human
Overview
| Product Description | Mouse Monoclonal antibody [32B12] recognizes AGRP / Agouti related protein |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IHC-P |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 32B12 |
| Isotype | IgG2 |
| Target Name | AGRP / Agouti related protein |
| Antigen Species | Human |
| Immunogen | Recombinant Human AGRP / Agouti related protein. |
| Conjugation | Un-conjugated |
| Alternate Names | Agouti-related protein; AGRT; ART; ASIP2 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Protein G chromatography |
| Buffer | PBS |
| Concentration | 0.2 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | AGRP |
| Gene Full Name | Agouti Related Neuropeptide |
| Background | This gene encodes an antagonist of the melanocortin-3 and melanocortin-4 receptor. It appears to regulate hypothalamic control of feeding behavior via melanocortin receptor and/or intracellular calcium regulation, and thus plays a role in weight homeostasis. Mutations in this gene have been associated with late on-set obesity. [provided by RefSeq, Dec 2009] |
| Function | Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R. [UniProt] |
| Cellular Localization | Golgi apparatus; Secreted. [UniProt] |
| Calculated MW | 14 kDa |
| PTM | Disulfide bond. [UniProt] |
Images (1) Click the Picture to Zoom In
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ARG45333 anti-AGRP / Agouti related protein antibody [32B12] IHC-P image
Immunohistochemistry: Human placental stained with ARG45330 anti-Inhibin beta B antibody [9M29].
