ARG45786
anti-ADAMTS5 antibody
anti-ADAMTS5 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes ADAMTS5 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | ADAMTS5 |
| Antigen Species | Human |
| Immunogen | Recombinant protein containing to human ADAMTS5. |
| Conjugation | Un-conjugated |
| Alternate Names | ADAMTS5; ADAM Metallopeptidase With Thrombospondin Type 1 Motif 5; ADAMTS11; ADMP-2; Aggrecanase-2; A Disintegrin-Like And Metalloprotease (Reprolysin Type) With Thrombospondin Type 1 Motif, 5 (Aggrecanase-2); A Disintegrin And Metalloproteinase With Thrombospondin Motifs 11; A Disintegrin And Metalloproteinase With Thrombospondin Motifs 5; ADAM-TS 11; ADAM-TS 5; ADAMTS-11; ADAM-TS5; ADAMTS-5; EC 3.4.24.14 47; EC 3.4.24.82 47; EC 3.4.24.-; EC 3.4.24 47; ADMP2 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Observed Size | 75 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified |
| Buffer | 0.2% Na2HPO4, 0.9% NaCl and 4% Trehalose. |
| Stabilizer | 4% Trehalose |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q9R001 Mouse A disintegrin and metalloproteinase with thrombospondin motifs 5 Swiss-port # Q9UNA0 Human A disintegrin and metalloproteinase with thrombospondin motifs 5 |
|---|---|
| Gene Symbol | ADAMTS5 |
| Gene Full Name | ADAM Metallopeptidase With Thrombospondin Type 1 Motif 5 |
| Background | This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs and functions as an aggrecanase that cleaves aggrecan, a major proteoglycan of cartilage, and may mediate cartilage destruction in osteoarthritis. [provided by RefSeq, Feb 2016] |
| Function | Metalloproteinase that plays an important role in connective tissue organization, development, inflammation and cell migration. Extracellular matrix (ECM) degrading enzyme that show proteolytic activity toward the hyalectan group of chondroitin sulfate proteoglycans (CSPGs) including ACAN, VCAN, BCAN and NCAN. [UniProt] |
| Cellular Localization | Extracellular matrix; Secreted. [UniProt] |
| Calculated MW | 102 kDa |
| PTM | Cleavage on pair of basic residues; Disulfide bond; Glycoprotein; Zymogen. [UniProt] |
