ARG57963

anti-ADAMTS1 antibody

Datasheet

Ordering Information

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Price (USD)

100 μl

389.00

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Datasheet

Overview

Product Description	Rabbit Polyclonal antibody recognizes ADAMTS1
Tested Reactivity	Hu, Ms, Rat
Tested Application	ICC/IF, WB
Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Target Name	ADAMTS1
Antigen Species	Human
Immunogen	Recombinant fusion protein corresponding to aa. 718-967 of Human ADAMTS1 (NP_008919.3).
Conjugation	Un-conjugated
Alternate Names	ADAMTS-1; A disintegrin and metalloproteinase with thrombospondin motifs 1; METH-1; METH1; EC 3.4.24.-; ADAM-TS1; C3-C5; ADAM-TS 1

Application Instructions

Application Suggestion

Tested Application	Dilution
ICC/IF	1:50 - 1:200
WB	1:200 - 1:2000

Application Note

* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Positive Control

Mouse liver

Observed Size

105 kDa

Properties

Form	Liquid
Purification	Affinity purified.
Buffer	PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol.
Preservative	0.02% Sodium azide
Stabilizer	50% Glycerol
Storage Instruction	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note	For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links	GeneID: 11504 Mouse ADAMTS1 GeneID: 9510 Human ADAMTS1 Swiss-port # P97857 Mouse A disintegrin and metalloproteinase with thrombospondin motifs 1 Swiss-port # Q9UHI8 Human A disintegrin and metalloproteinase with thrombospondin motifs 1
Gene Symbol	ADAMTS1
Gene Full Name	ADAM metallopeptidase with thrombospondin type 1 motif, 1
Background	This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two disintegrin loops and three C-terminal TS motifs and has anti-angiogenic activity. The expression of this gene may be associated with various inflammatory processes as well as development of cancer cachexia. This gene is likely to be necessary for normal growth, fertility, and organ morphology and function. [provided by RefSeq, Jul 2008]
Function	Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover (By similarity). Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture. [UniProt]
Cellular Localization	Secreted, extracellular matrix, extracellular space. [UniProt]
Calculated MW	105 kDa
PTM	The precursor is cleaved by a furin endopeptidase. Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity). [UniProt]