ARG23353
anti-ADAM10 / KUZ / MADM antibody [11G2] (azide free)
anti-ADAM10 / KUZ / MADM antibody [11G2] (azide free) for Flow cytometry,Immunoprecipitation,Western blot and Human
Overview
| Product Description | Azide free Mouse Monoclonal antibody [11G2] recognizes ADAM10 / KUZ / MADM |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | FACS, IP, WB |
| Specificity | This antibody recognizes the ADAM-10 protein, either the 70 kDa form or the 97 kDa precursor form. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 11G2 |
| Isotype | IgG1 |
| Target Name | ADAM10 / KUZ / MADM |
| Antigen Species | Human |
| Immunogen | Jurkat cell line |
| Conjugation | Un-conjugated |
| Alternate Names | Kuzbanian protein homolog; kuz; HsT18717; MADM; RAK; EC 3.4.24.81; ADAM 10; AD18; CDw156; Mammalian disintegrin-metalloprotease; CD antigen CD156c; AD10; Disintegrin and metalloproteinase domain-containing protein 10; CD156c |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification Note | Sterile-filtered through 0.22 µm. |
| Buffer | PBS |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # O14672 Human Disintegrin and metalloproteinase domain-containing protein 10 |
|---|---|
| Gene Symbol | ADAM10 |
| Gene Full Name | ADAM metallopeptidase domain 10 |
| Background | Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin. [provided by RefSeq, Jul 2008] |
| Function | Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis. Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form. Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B. May regulate the EFNA5-EPHA3 signaling. [UniProt] |
| Calculated MW | 84 kDa |
| PTM | The precursor is cleaved by a furin endopeptidase. [UniProt] |
