ARG43380
anti-ACVR1C / ALK7 antibody
anti-ACVR1C / ALK7 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes ACVR1C / ALK7 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | ACVR1C / ALK7 |
| Antigen Species | Human |
| Immunogen | Recombinant fusion protein corresponding to aa. 22-113 of Human ACVR1C / ALK7 (NP_660302.2). |
| Conjugation | Un-conjugated |
| Alternate Names | ALK7; EC 2.7.11.30; Activin receptor-like kinase 7; Activin receptor type IC; ACVRLK7; ALK-7; ACTR-IC; Activin receptor type-1C |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Positive Control | SH-SY5Y | ||||||
| Observed Size | ~ 60 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | ACVR1C |
| Gene Full Name | activin A receptor, type IC |
| Background | ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors (Bondestam et al., 2001 [PubMed 12063393]).[supplied by OMIM, Mar 2008] |
| Function | Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis. [UniProt] |
| Cellular Localization | Membrane; Single-pass type I membrane protein. [UniProt] |
| Calculated MW | 55 kDa |
Images (2) Click the Picture to Zoom In
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ARG43380 anti-ACVR1C / ALK7 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Mouse stomach tissue stained with ARG43380 anti-ACVR1C / ALK7 antibody at 1:100 dilution.
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ARG43380 anti-ACVR1C / ALK7 antibody WB image
Western blot: 25 µg of SH-SY5Y cell lysate stained with ARG43380 anti-ACVR1C / ALK7 antibody at 1:1000 dilution.
