ARG64410
anti-ACVR1 / ALK2 antibody
anti-ACVR1 / ALK2 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
Developmental Biology antibody; Gene Regulation antibody; Signaling Transduction antibody
Overview
| Product Description | Goat Polyclonal antibody recognizes ACVR1 / ALK2 |
|---|---|
| Tested Reactivity | Hu |
| Predict Reactivity | Ms, Rat, Dog |
| Tested Application | IHC-P, WB |
| Host | Goat |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | ACVR1 / ALK2 |
| Antigen Species | Human |
| Immunogen | C-RKFKRRNQERLNPRD |
| Conjugation | Un-conjugated |
| Alternate Names | ALK2; ACTRI; FOP; Serine/threonine-protein kinase receptor R1; Activin receptor type I; EC 2.7.11.30; Activin receptor-like kinase 2; TSRI; ACVRLK2; Activin receptor type-1; SKR1; ACVR1A; ACTR-I; TGF-B superfamily receptor type I; TSR-I; ALK-2 |
Application Instructions
| Application Suggestion |
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|---|---|---|---|---|---|---|---|
| Application Note | IHC-P: Antigen Retrieval: Steam tissue section in Citrate buffer (pH 6.0). WB: Recommend incubate at RT for 1h. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Buffer | Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 0.5% BSA |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | ACVR1 |
| Gene Full Name | activin A receptor type 1 |
| Background | Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive. [provided by RefSeq, Jul 2008] |
| Research Area | Developmental Biology antibody; Gene Regulation antibody; Signaling Transduction antibody |
| Calculated MW | 57 kDa |
Images (2) Click the Picture to Zoom In
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ARG64410 anti-ACVR1 / ALK2 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human testis (steamed antigen retrieval with citrate buffer pH 6.0) stained with ARG64410 anti-ACVR1 / ALK2 antibody at 4 µg/ml dilution followed by AP-staining.
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ARG64410 anti-ACVR1 / ALK2 antibody WB image
Western blot: 35 µg of Human umbilical cord lysate (in RIPA buffer) stained with ARG64410 anti-ACVR1 / ALK2 antibody at 0.3 µg/ml dilution and incubated at RT for 1 hour.
