ARG70408
Pig IL17 / IL17A recombinant protein (His-tagged, C-ter)
Pig IL17 / IL17A recombinant protein (His-tagged, C-ter) for SDS-PAGE
Overview
| Product Description | E. coli expressed, His-tagged (C-ter) Pig IL17 / IL17A recombinant protein |
|---|---|
| Tested Application | SDS-PAGE |
| Target Name | IL17 / IL17A |
| Species | Pig |
| A.A. Sequence | Gly26 - Ser155 |
| Expression System | E. coli |
| Protein Full Name | Interleukin-17A |
| Alternate Names | IL17A; Interleukin 17A; IL-17A; IL-17; CTLA8; IL17; Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8); Cytotoxic T-Lymphocyte-Associated Protein 8; Cytotoxic T-Lymphocyte-Associated Antigen 8; Interleukin-17A; CTLA-8; Interleukin-17; ILA17 |
Properties
| Form | Powder |
|---|---|
| Purification Note | Endotoxin level is <0.1 EU/µg of the protein, as determined by the LAL test. |
| Purity | >98% (by SDS-PAGE) |
| Buffer | PBS (pH 7.4) |
| Reconstitution | It is recommended to reconstitute the lyophilized protein in sterile water to a concentration not <200 μg/mL and incubate the stock solution for at least 20 min at room temperature to make sure the protein is dissolved completely. |
| Storage Instruction | For long term, lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C or -80°C for up to one month. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Symbol | IL17A |
|---|---|
| Gene Full Name | Interleukin 17A |
| Background | This gene is a member of the IL-17 receptor family which includes five members (IL-17RA-E) and the encoded protein is a proinflammatory cytokine produced by activated T cells. IL-17A-mediated downstream pathways induce the production of inflammatory molecules, chemokines, antimicrobial peptides, and remodeling proteins. The encoded protein elicits crucial impacts on host defense, cell trafficking, immune modulation, and tissue repair, with a key role in the induction of innate immune defenses. This cytokine stimulates non-hematopoietic cells and promotes chemokine production thereby attracting myeloid cells to inflammatory sites. This cytokine also regulates the activities of NF-kappaB and mitogen-activated protein kinases and can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). IL-17A plays a pivotal role in various infectious diseases, inflammatory and autoimmune disorders, and cancer. High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. The lung damage induced by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is to a large extent, a result of the inflammatory response promoted by cytokines such as IL17A. |
| Function | Effector cytokine of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. |
| Cellular Localization | Secreted |
| PTM | Disulfide bond, Glycoprotein |
Images (1) Click the Picture to Zoom In
-
ARG70408 Pig IL17 / IL17A recombinant protein (His-tagged, C-ter) SDS-PAGE image
SDS-PAGE analysis of ARG70408 Pig IL17 / IL17A recombinant protein (His-tagged, C-ter)
